Efficiency of Electronic Health Record Assessment of Patient-Reported Outcomes After Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.4427
Abstract: Key Points Question Can an electronic patient-reported outcome (ePRO) model improve outcome in cancer immunotherapy compared with a traditional model? Findings In this randomized clinical trial of 278 patients from 28 Chinese hospitals comparing ePRO… read more here.
Keywords: patient reported; cancer; model; cancer immunotherapy ... See more keywords
Bacterium‐Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity
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DOI: 10.1002/adfm.201901437
Abstract: Bacteria are utilized as adjuvants for anticancer immunotherapy. However, immunotherapy with bacteria or their extracts is limited due to their toxicity. On the basis of the innate molecular interactions of foreign molecules from the bacterial… read more here.
Keywords: minimized toxicity; bacterium; bacterium mimicking; cancer immunotherapy ... See more keywords
Immune Cycle‐Based Strategies for Cancer Immunotherapy
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DOI: 10.1002/adfm.202107540
Abstract: The immune system is composed of immune organs, immune cells, and immunoactive substances, which plays a vital role in antitumor immunity in cancer immunotherapy. During the process of the antitumor immune response, many factors are… read more here.
Keywords: cancer; cancer immune; immune cycle; cancer immunotherapy ... See more keywords
Diselenide‐Based Dual‐Responsive Prodrug as Pyroptosis Inducer Potentiates Cancer Immunotherapy
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DOI: 10.1002/adhm.202202135
Abstract: Pyroptosis is demonstrated to trigger antitumor immunity and represents a promising new strategy to potentiate cancer immunotherapy. The number of potent pyroptosis inducers, however, is limited and without tumor‐targeting capability, which inevitably causes damage in… read more here.
Keywords: dual responsive; pyroptosis; dse poc; cancer immunotherapy ... See more keywords
Oxidative Stress Amplifiers as Immunogenic Cell Death Nanoinducers Disrupting Mitochondrial Redox Homeostasis for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202710
Abstract: Reactive oxygen species (ROS)‐induced oxidative stress in the endoplasmic reticulum (ER) is generally believed to be an important prerequisite for immunogenic cell death (ICD) which can trigger antitumor immune responses for cancer immunotherapy. However, thus… read more here.
Keywords: cell; stress; oxidative stress; cancer ... See more keywords
Peptide Hydrogels as Immunomaterials and Their Use in Cancer Immunotherapy Delivery.
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DOI: 10.1002/adhm.202301096
Abstract: Peptide-based hydrogel biomaterials have emerged as an excellent strategy for immune system modulation. Peptide-based hydrogels are supramolecular materials that self-assemble into various nanostructures through various interactive forces (i.e., hydrogen bonding and hydrophobic interactions) and respond… read more here.
Keywords: system; peptide hydrogels; delivery; cancer ... See more keywords
Photoactivatable Silencing Extracellular Vesicle (PASEV) Sensitizes Cancer Immunotherapy
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DOI: 10.1002/adma.202204765
Abstract: Immunotherapy has delivered impressive outcomes in combating tumor malignancies. However, insufficient immune infiltration and poor immunogenicity within the tumor microenvironment (TME) greatly compromise patient response rates. Here, a photoactivatable silencing extracellular vesicle (PASEV) is developed… read more here.
Keywords: immunotherapy; extracellular vesicle; photoactivatable silencing; silencing extracellular ... See more keywords
Near‐Infrared Nano‐Optogenetic Activation of Cancer Immunotherapy via Engineered Bacteria
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DOI: 10.1002/adma.202207198
Abstract: Certain anaerobic microbes with the capability to colonize the tumor microenvironment tend to express the heterologous gene in a sustainable manner, which will inevitably compromise the therapeutic efficacy and induce off‐tumor toxicity in vivo. To… read more here.
Keywords: nano optogenetic; tumor; near infrared; cancer immunotherapy ... See more keywords
DNA Nanoclusters Combined with One‐Shot Radiotherapy Augment Cancer Immunotherapy Efficiency
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DOI: 10.1002/adma.202208546
Abstract: Immunotherapy shows immense promise for improving cancer treatment. Combining immunotherapy with radiotherapy provides a conspicuous advantage due to its enhanced abscopal effect. However, established immune tolerance mechanisms in the tumor microenvironment can hamper the generation… read more here.
Keywords: dna; immunotherapy; radiotherapy; efficiency ... See more keywords
Reprogramming Hypoxic Tumor-associated Macrophages by Nanoglycoclusters for Boosted Cancer Immunotherapy.
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DOI: 10.1002/adma.202211332
Abstract: The tumor-associated macrophages (TAMs) in intratumoral hypoxic regions are key drivers of immune escape. Reprogramming the hypoxic TAMs to antitumor phenotype holds great therapeutic benefits but remains challenging for current drugs. Here, we report an… read more here.
Keywords: associated macrophages; tumor; reprogramming hypoxic; tumor associated ... See more keywords
Organic Sonodynamic Materials for Combination Cancer Immunotherapy.
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DOI: 10.1002/adma.202303059
Abstract: Sonodynamic therapy (SDT) has been a promising non-invasive therapeutic modality to treat deep-seated tumors owing to the good tissue penetration ability and spatiotemporal controllability of ultrasound (US); however, the low sonodynamic activity and potential side… read more here.
Keywords: oncology; combination cancer; cancer; cancer immunotherapy ... See more keywords