MicroRNA‐506 ameliorates breast cancer‐induced osteolytic bone metastasis via the NFATc‐1 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23156
Abstract: Breast cancer is becoming a common life‐threatening disease, especially in women, along with higher incidence and mortality. MicroRNA (miR)−506 was reported to participate in breast cancer progression, while the role of miR‐506 in breast cancer‐induced… read more here.
Keywords: bone; cancer induced; breast cancer; mir 506 ... See more keywords
Molecular and Physiological Evaluation of Pancreatic Cancer-Induced Cachexia.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8879-2_28
Abstract: Cachexia, a complex metabolic syndrome, is characterized by involuntary weight loss along with muscle wasting and fat depletion leading to poor quality of life of patients. About 80% of pancreatic cancer patients exhibit cachectic phenotype at… read more here.
Keywords: pancreatic cancer; induced cachexia; evaluation; cancer ... See more keywords
Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.11.003
Abstract: Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby… read more here.
Keywords: induced endoplasmic; endoplasmic reticulum; reticulum stress; stress cells ... See more keywords
Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174412
Abstract: Due to the efficacy and tolerability of the available drugs, the current treatment for cancer-induced bone pain (CIBP) is not considered ideal, and new drugs are required for better treatment results. This study investigated whether… read more here.
Keywords: enhances analgesic; induced bone; bone; cancer ... See more keywords
Activation of the spinal EGFR signaling pathway in a rat model of cancer-induced bone pain with morphine tolerance
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108703
Abstract: Cancer-induced bone pain (CIBP) is considered to be one of the most difficult pain conditions to treat. Morphine, an analgesic drug, is widely used in clinical practice, and long-term use of morphine can lead to… read more here.
Keywords: tolerance; induced bone; cancer; bone pain ... See more keywords
Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.10.011
Abstract: Cancer-induced bone pain (CIBP) is a frequent complication in patients suffering from bone metastases. Previous studies have demonstrated a pivotal role of reactive oxygen species (ROS) in inflammatory and neuropathic pain, and ROS scavengers exhibited… read more here.
Keywords: cibp; induced bone; bone; cancer induced ... See more keywords
Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Pain"
DOI: 10.1016/j.sjpain.2016.09.011
Abstract: Abstract Background The first line pharmacological treatment of cancer pain is morphine and surrogates but a significant pain relief and a reduction of the side-effects of these compounds makes it necessary to combine them with… read more here.
Keywords: pl265; induced bone; cancer; receptor ... See more keywords
Cobratoxin Alleviates Cancer-Induced Bone Pain in Rats via Inhibiting CaMKII Signaling Pathway after Acting on M4 Muscarinic Cholinergic Receptors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00048
Abstract: Cancer-induced bone pain (CIBP) is a common pain in clinics, which can reduce the quality of life and increase the mortality of patients, but the treatment of CIBP is limited. This study was designed to… read more here.
Keywords: cancer induced; muscarinic cholinergic; pain; camkii ... See more keywords
MacroH2A1.2 Inhibits Prostate Cancer-induced Osteoclastogenesis through Cooperation with HP1α and H1.2
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0356-3
Abstract: Osteoclasts are multinuclear bone-resorbing cells that differentiate from hematopoietic precursor cells. Prostate cancer cells frequently spread to bone and secrete soluble signaling factors to accelerate osteoclast differentiation and bone resorption. However, processes and mechanisms that… read more here.
Keywords: induced osteoclastogenesis; prostate cancer; bone; cancer cells ... See more keywords
Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02347-2
Abstract: Cancer-induced cachexia, characterized by muscle wasting, is a lethal metabolic syndrome with undefined etiology. Current consensus is that multiple factors contribute to cancer-induced muscle wasting, and therefore therapy requires combinational strategies. Here, we show that… read more here.
Keywords: toll like; muscle; like receptor; induced muscle ... See more keywords
Pancreatic Cancer-Induced Cachexia and Relevant Mouse Models.
Sign Up to like & getrecommendations! Published in 2018 at "Pancreas"
DOI: 10.1097/mpa.0000000000001124
Abstract: Pancreatic cancer is the third leading cause of cancer death in the United States, with projections that it will become the second leading cause by the year 2030. It carries a dismal prognosis with a… read more here.
Keywords: mouse models; models pancreatic; pancreatic cancer; cancer ... See more keywords