Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.05.003
Abstract: How fully differentiated cells that experience carcinogenic insults become proliferative cancer progenitors that acquire multiple initiating mutations is not clear. This question is of particular relevance to hepatocellular carcinoma (HCC), which arises from differentiated hepatocytes.… read more here.
Keywords: initiation requires; cd44; cancer initiation; cancer ... See more keywords
Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-019-0359-5
Abstract: Human liver cancers, including hepatocellular carcinomas and intra-hepatic cholangiocarcinomas, are often diagnosed late with poor prognosis. A better understanding of cancer initiation could provide potential preventive therapies and increase survival. Models for studying human liver… read more here.
Keywords: initiation; cancer initiation; cancer; directly reprogrammed ... See more keywords
The role of spatial structures of tissues in cancer initiation dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Physical Biology"
DOI: 10.1088/1478-3975/ac8515
Abstract: It is widely believed that biological tissues evolved to lower the risks of cancer development. One of the specific ways to minimize the chances of tumor formation comes from proper spatial organization of tissues. However,… read more here.
Keywords: cancer initiation; spatial structures; cancer; role spatial ... See more keywords
Resilience function uncovers the critical transitions in cancer initiation.
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab175
Abstract: Considerable evidence suggests that during the progression of cancer initiation, the state transition from wellness to disease is not necessarily smooth but manifests switch-like nonlinear behaviors, preventing the cancer prediction and early interventional therapy for… read more here.
Keywords: state; resilience function; resilience; cancer initiation ... See more keywords
Abstract 4448: Elevated levels of circulating miR-34a-5p and miR-181c-3p during cancer initiation by aflatoxin B1
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4448
Abstract: MicroRNAs are small non-coding RNAs that affect gene expression. They are essential in normal physiological processes and have been implicated in carcinogenesis. Hepatocellular carcinoma (HCC) is the second leading cause of cancer death globally, with… read more here.
Keywords: mir 34a; mir; mir 181c; cancer initiation ... See more keywords
Tracing the path of cancer initiation: the AA protein-based model for cancer genesis
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4739-1
Abstract: BackgroundCancer is a defiant disease which cure is still far from being attained besides the colossal efforts and financial means deployed towards that end. The continuing setbacks encountered with today’s arsenal of anti-cancer drugs and… read more here.
Keywords: protein based; model; cancer initiation; cancer ... See more keywords
Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression
Sign Up to like & getrecommendations! Published in 2018 at "Biomedicines"
DOI: 10.3390/biomedicines6030082
Abstract: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation of a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. At the same… read more here.
Keywords: transcription factor; factor; cancer initiation; tumor ... See more keywords
Cellular Carcinogenesis: Role of Polarized Macrophages in Cancer Initiation
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DOI: 10.3390/cancers14112811
Abstract: Simple Summary Inflammation is a hallmark of many cancers. Macrophages are key participants in innate immunity and important drivers of inflammation. When chronically polarized beyond normal homeostatic responses to infection, injury, or aging, macrophages can… read more here.
Keywords: inflammation; cancer; polarized macrophages; carcinogenesis ... See more keywords
Homeostasis and Cancer Initiation: Organoids as Models to Study the Initiation of Gastric Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052790
Abstract: Gastric cancer represents a significant disease burden worldwide. The factors that initiate cancer are not well understood. Chronic inflammation such as that triggered by H. pylori infection is the most significant cause of gastric cancer.… read more here.
Keywords: cancer; homeostasis; gastric cancer; stem cells ... See more keywords