XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin‐mediated Rho‐GDIβ mRNA stability
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31223
Abstract: Our recent studies demonstrate that X‐linked inhibitor of apoptosis protein (XIAP) is essential for regulating colorectal cancer invasion. Here, we discovered that RhoGDIβ was a key XIAP downstream effector mediating bladder cancer (BC) invasion in… read more here.
Keywords: cancer; xiap; cancer invasion; lung metastasis ... See more keywords
Blow-Up Phenomena of a Cancer Invasion Model with Nonlinear Diffusion and Haptotaxis Term
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of the Malaysian Mathematical Sciences Society"
DOI: 10.1007/s40840-020-00996-7
Abstract: In this paper, we consider a nonlinear cancer invasion mathematical model with proliferation, growth and haptotaxis effects. We obtain lower bounds for the finite-time blow-up of solutions of the considered system with nonlinear diffusion operator… read more here.
Keywords: blow; model; cancer invasion; nonlinear diffusion ... See more keywords
The complex ecosystem in non small cell lung cancer invasion
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006131
Abstract: Many tumors are characterized by genetic instability, producing an assortment of genetic variants of tumor cells called subclones. These tumors and their surrounding environments form complex multi-cellular ecosystems, where subclones compete for resources and cooperate… read more here.
Keywords: ecosystem; cancer invasion; lung cancer; cancer ... See more keywords
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17279
Abstract: Patients with advanced bladder cancer have poor outcomes, indicating a need for more efficient therapeutic approaches. This study characterizes proteomic changes underlying bladder cancer invasion aiming for the better understanding of disease pathophysiology and identification… read more here.
Keywords: bladder cancer; analysis; bladder; muscle invasive ... See more keywords
Perspectives of Plant Natural Products in Inhibition of Cancer Invasion and Metastasis by Regulating Multiple Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170918123413
Abstract: BACKGROUND Metastasis is often derived from increased invasion and migration of tumor cells, and is the most frequent cause of cancer-associated death. Either the prophylactic or therapeutic treatment of metastatic cancer remains very challenging today… read more here.
Keywords: cancer; invasion metastasis; cancer invasion; plant ... See more keywords
RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.665273
Abstract: Activity of transcription factors is normally regulated through interaction with other transcription factors, chromatin remodeling proteins and transcriptional co-activators. In distinction to these well-established transcriptional controls of gene expression, we have uncovered a unique activation… read more here.
Keywords: kinase; cancer invasion; cancer; kinase abl ... See more keywords