Durvalumab and tremelimumab in combination with FOLFOX in patients with RAS-mutated, microsatellite-stable, previously untreated metastatic colorectal cancer (MCRC): Results of the first intermediate analysis of the phase Ib/II MEDETREME trial.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.3006
Abstract: 3006Background: Single agent PD-1/L1 inhibition are not effective in metastatic colorectal cancer (MCRC) with microsatellite stable tumors. However, signal of efficacy was shown using combo therapy... read more here.
Keywords: cancer mcrc; metastatic colorectal; colorectal cancer; microsatellite stable ... See more keywords
BRCA mutations in metastatic colorectal cancer (mCRC) and response to chemotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.235
Abstract: 235Background: Mutations in BRCA 1/2 are typically associated with breast, ovarian, pancreatic and prostate cancers. BRCA mutations have been reported in colorectal cancer in sporadic case series. ... read more here.
Keywords: cancer mcrc; metastatic colorectal; mutations metastatic; colorectal cancer ... See more keywords
Efficacy and safety of FOLFIRI/aflibercept (FA) in an elderly population with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin-based regimen
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DOI: 10.1371/journal.pone.0269399
Abstract: Background The VELOUR study showed the benefit of FOLFIRI-Aflibercept (FA) versus FOLFIRI in patients with metastatic colorectal cancer (mCRC) in second-line treatment. However, only 36% of the included patients were ≥65 years. Thus, we seek… read more here.
Keywords: patients years; cancer mcrc; metastatic colorectal; folfiri ... See more keywords
TGF-β Signaling in Metastatic Colorectal Cancer (mCRC): From Underlying Mechanism to Potential Applications in Clinical Development
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DOI: 10.3390/ijms232214436
Abstract: Colorectal cancer (CRC) is a serious public health issue, and it has the leading incidence and mortality among malignant tumors worldwide. CRC patients with metastasis in the liver, lung or other distant sites always have… read more here.
Keywords: cancer mcrc; metastatic colorectal; colorectal cancer; mcrc ... See more keywords