T cell exhaustion in cancer: Mechanisms and clinical implications
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26645
Abstract: During chronic viral infection or cancer, the immune system usually induces a corresponding immune response against pathogens or cancer cells so as to prevent worsening disease. T cell exhaustion in which reduced and dysfunctional effector… read more here.
Keywords: cancer; exhaustion cancer; cancer mechanisms; cell exhaustion ... See more keywords
Research progress on the source, production, and anti-cancer mechanisms of paclitaxel.
Sign Up to like & getrecommendations! Published in 2020 at "Chinese journal of natural medicines"
DOI: 10.1016/s1875-5364(20)60032-2
Abstract: Paclitaxel, a tetracyclic diterpenoid compounds, was firstly isolated from the bark of the Pacific yew trees. Currently, as a low toxicity, high efficiency, and broad-spectrum natural anti-cancer drug, paclitaxel has been widely used against ovarian… read more here.
Keywords: production anti; cancer; anti cancer; cancer mechanisms ... See more keywords
Mechanisms associated with biogenesis of exosomes in cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer"
DOI: 10.1186/s12943-019-0963-9
Abstract: Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles… read more here.
Keywords: associated biogenesis; mechanisms associated; biogenesis exosomes; exosomes cancer ... See more keywords
Stress and cancer: The mechanisms of immune dysregulation and management
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1032294
Abstract: Advances in the understanding of psychoneuroimmunology in the past decade have emphasized the notion that stress and cancer are interlinked closely. Durable chronic stress accelerated tumorigenesis and progression, which is unfavorable for clinical outcomes of… read more here.
Keywords: stress cancer; stress; cancer mechanisms; management ... See more keywords
Alternative Lengthening of Telomeres in Pediatric Cancer: Mechanisms to Therapies
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01518
Abstract: Achieving replicative immortality is a crucial step in tumorigenesis and requires both bypassing cell cycle checkpoints and the extension of telomeres, sequences that protect the distal ends of chromosomes during replication. In the majority of… read more here.
Keywords: alternative lengthening; telomeres pediatric; mechanisms therapies; pediatric cancer ... See more keywords
Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1106762
Abstract: Pancreatic cancer (PC) is a malignant tumor with high malignancy that is difficult to diagnose and treat. PC is a major medical problem because of its low early diagnosis rate, high surgical mortality rate, low… read more here.
Keywords: semaphorins receptors; receptors pancreatic; pancreatic cancer; mechanisms therapeutic ... See more keywords
Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12091224
Abstract: Wilms’ tumor 1-associating protein (WTAP) is required for N6-methyladenosine (m6A) RNA methylation modifications, which regulate biological processes such as RNA splicing, cell proliferation, cell cycle, and embryonic development. m6A is the predominant form of mRNA… read more here.
Keywords: wtap; role; role wtap; cancer mechanisms ... See more keywords
FAK in Cancer: From Mechanisms to Therapeutic Strategies
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031726
Abstract: Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and activated in many cancer types. FAK regulates diverse cellular processes, including growth factor signaling, cell cycle progression, cell survival, cell motility, angiogenesis, and the… read more here.
Keywords: therapeutic strategies; fak cancer; mechanisms therapeutic; fak ... See more keywords
NK Cells in Cancer: Mechanisms of Dysfunction and Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119521
Abstract: Natural killer cells (NK) are innate lymphocytes endowed with the ability to recognize and kill cancer cells. Consequently, adoptive transfer of autologous or allogeneic NK cells represents a novel opportunity in cancer treatment that is… read more here.
Keywords: mechanisms dysfunction; therapeutic potential; cancer mechanisms; cells cancer ... See more keywords