Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.06.003
Abstract: The enzyme glutaminase (GLS1) is currently in clinical trials for oncology, yet there are no clear diagnostic criteria to identify responders. The evaluation of 25 basal breast lines expressing GLS1, predominantly through its splice isoform… read more here.
Keywords: pan cancer; cancer metabolic; novo glutathione; glutathione synthesis ... See more keywords
Comorbidities involving parasitic diseases: A look at the benefits and complications
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221108387
Abstract: Parasitic infections acquired by the population cause substantial morbidity worldwide, with individuals from developing countries being most affected. Some parasites remain in the host for long periods, settling in different organs, manipulating the flow of… read more here.
Keywords: comorbidities involving; cancer metabolic; involving parasitic; parasitic diseases ... See more keywords
CaMeRe: A Novel Tool for Inference of Cancer Metabolic Reprogramming
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00207
Abstract: Metabolic reprogramming is prevalent in cancer, largely due to its altered chemical environments such as the distinct intracellular concentrations of O2, H2O2 and H+, compared to those in normal tissue cells. The reprogrammed metabolisms are… read more here.
Keywords: cancer metabolic; metabolic reprogramming; tool; inference cancer ... See more keywords
Cancer as a Metabolic Disorder
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031155
Abstract: Cancer has long been considered a genetic disease characterized by a myriad of mutations that drive cancer progression. Recent accumulating evidence indicates that the dysregulated metabolism in cancer cells is more than a hallmark of… read more here.
Keywords: cancer; cancer metabolic; metabolic disorder;
Diabetes and Cancer: Metabolic Association, Therapeutic Challenges, and the Role of Natural Products
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26082179
Abstract: Cancer is considered the second leading cause of death worldwide and in 2018 it was responsible for approximately 9.6 million deaths. Globally, about one in six deaths are caused by cancer. A strong correlation was… read more here.
Keywords: cancer metabolic; natural products; association therapeutic; metabolic association ... See more keywords
Gastric cancer: Metabolic and metabolomics perspectives (Review).
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4000
Abstract: Gastric cancer is one of the most malignant tumors worldwide and remains a major health threat in Asia-Pacific regions, while its pathological mechanism is generally unknown. Recent research has advanced the understanding of the relationship… read more here.
Keywords: cancer metabolic; gastric cancer; metabolic metabolomics; metabolomics perspectives ... See more keywords