The Intricate Metabolism of Pancreatic Cancers.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-65768-0_5
Abstract: Currently, approximately 95% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC), which are the most aggressive form and the fourth leading cause of cancer death with extremely poor prognosis [1]. Poor prognosis is primarily attributed… read more here.
Keywords: metabolism; metabolism pancreatic; pancreatic cancers; intricate metabolism ... See more keywords
Breast Cancer Metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-77736-8_6
Abstract: KEY POINTS Despite advances in screening, therapy, and surveillance that have improved survival rates, breast cancer is still the most commonly diagnosed cancer and the second leading cause of cancer mortality among women [1]. Breast… read more here.
Keywords: cancer; biology; cancer metabolism; breast cancer ... See more keywords
Physiological functions of FBW7 in cancer and metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.02.009
Abstract: FBW7 is one of the most well characterized F-box proteins that serve as substrate recognition subunits of SCF (Skp1-Cullin 1-F-box proteins) E3 ubiquitin ligase complexes. SCFFBW7 plays key roles in regulating cell cycle progression, differentiation,… read more here.
Keywords: physiological functions; functions fbw7; cancer metabolism; fbw7 cancer ... See more keywords
SnapShot: Cancer metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.06.021
Abstract: Metabolic networks support cancer cell survival, proliferation, and malignant progression. Cancer cells take up large amounts of nutrients such as glucose and glutamine whose metabolism provides the energy, reducing equivalents, and biosynthetic precursors required to… read more here.
Keywords: cancer; metabolism; snapshot cancer; cancer metabolism ... See more keywords
Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01231
Abstract: Previously, we reported a hypoxia-inducible factor (HIF)-1 inhibitor LW6 containing an (aryloxyacetylamino)benzoic acid moiety inhibits malate dehydrogenase 2 (MDH2) using a chemical biology approach. Structure-activity relationship studies on a series of (aryloxyacetylamino)benzoic acids identified selective… read more here.
Keywords: mdh2; inhibitor; malate dehydrogenase; cancer metabolism ... See more keywords
Cancer metabolism: looking forward
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Cancer"
DOI: 10.1038/s41568-021-00378-6
Abstract: Tumour initiation and progression requires the metabolic reprogramming of cancer cells. Cancer cells autonomously alter their flux through various metabolic pathways in order to meet the increased bioenergetic and biosynthetic demand as well as mitigate… read more here.
Keywords: metabolism looking; metabolism; metabolic pathways; cancer metabolism ... See more keywords
Extracellular Citrate and Cancer Metabolism-Response.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-1899
Abstract: In response to our recent article showing that cancer cells take up extracellular citrate through the plasma membrane-specific variant (pmCiC) of the mitochondrial citrate transporter and that depriving cancer cells of extracellular citrate by blocking… read more here.
Keywords: response; citrate; citrate cancer; cancer metabolism ... See more keywords
Abstract IA24: Imaging cancer metabolism in patients: Beyond FDG PET
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.epimetab20-ia24
Abstract: Molecular imaging is a tool that can visualize and quantify biological processes at the molecular and cellular levels in living systems1, and it is therefore ideally suited to the study of cancer metabolism in patients2.… read more here.
Keywords: imaging cancer; metabolism; fdg pet; cancer metabolism ... See more keywords
Diet and Exercise in Cancer Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-22-0096
Abstract: Summary: Diet and exercise are modifiable lifestyle factors known to have a major influence on metabolism. Clinical practice addresses diseases of altered metabolism such as diabetes or hypertension by altering these factors. Despite enormous public… read more here.
Keywords: diet exercise; metabolism; cancer metabolism; exercise cancer ... See more keywords
Lessons from Cancer Metabolism for Pulmonary Arterial Hypertension and Fibrosis.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2020-0550tr
Abstract: Metabolism is essential for a living-organism to sustain life. It provides energy to a cell by breaking down compounds (catabolism), and supplies building blocks for the synthesis of macromolecules (anabolism). Signal transduction pathways tightly regulate… read more here.
Keywords: hypertension fibrosis; cancer metabolism; pulmonary arterial; cancer ... See more keywords
The emerging role of deubiquitylating enzymes as therapeutic targets in cancer metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cell International"
DOI: 10.1186/s12935-022-02524-y
Abstract: Cancer cells must rewire cellular metabolism to satisfy the unbridled proliferation, and metabolic reprogramming provides not only the advantage for cancer cell proliferation but also new targets for cancer treatment. However, the plasticity of the… read more here.
Keywords: cancer; cancer cell; targets cancer; cancer metabolism ... See more keywords