Engineered macrophages based uPA-scavenger load gemcitabine to prompt robust treating cancer metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203356
Abstract: The majority of cancer patients die of metastasis rather than primary tumors, and most patients may have already completed the cryptic metastatic process at the time of diagnosis, making them intractable for therapeutic intervention. The… read more here.
Keywords: metastasis; upa scavenger; cancer metastasis; tumor ... See more keywords
Organic Electronic Platform for Real-time Phenotypic Screening of Extracellular Vesicle-driven Breast Cancer Metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202301194
Abstract: Tumour-derived extracellular vesicles (TEVs) induce the epithelial-to-mesenchymal transition (EMT) in non-malignant cells to promote invasion and cancer metastasis, representing a novel therapeutic target in a field severely lacking in efficacious anti-metastasis treatments. However, scalable technologies… read more here.
Keywords: metastasis; platform; breast; cancer metastasis ... See more keywords
Small Molecular Inhibitors Reverse Cancer Metastasis by Blockading Oncogenic PITPNM3
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204649
Abstract: Most cancer‐related deaths are a result of metastasis. The development of small molecular inhibitors reversing cancer metastasis represents a promising therapeutic opportunity for cancer patients. This pan‐cancer analysis identifies oncogenic roles of membrane‐associated phosphatidylinositol transfer… read more here.
Keywords: metastasis; cancer metastasis; pitpnm3; small molecular ... See more keywords
Effects of propofol on colon cancer metastasis through STAT3/HOTAIR axis by activating WIF‐1 and suppressing Wnt pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2840
Abstract: In the present study, we aim to investigate the potential role of propofol in the tumor progression of colon cancer. read more here.
Keywords: cancer metastasis; propofol colon; colon cancer; cancer ... See more keywords
MiR-503 pleiotropically regulates epithelial-mesenchymal transition and targets PTK7 to control lung cancer metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6116
Abstract: OBJECTIVE In lung cancer patients, most deaths are caused by the distant dissemination of cancer cells. Epithelial-mesenchymal transition (EMT) and collective cell migration are distinct and important mechanisms involved in cancer invasion and metastasis. Additionally,… read more here.
Keywords: lung cancer; cancer; cancer metastasis; mir 503 ... See more keywords
Quantitative Proteomics of Hepatic Drug‐Metabolizing Enzymes and Transporters in Patients With Colorectal Cancer Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2633
Abstract: The impact of liver cancer metastasis on protein abundance of 22 drug‐metabolizing enzymes (DMEs) and 25 transporters was investigated using liquid chromatography‐tandem accurate mass spectrometry targeted proteomics. Microsomes were prepared from liver tissue taken from… read more here.
Keywords: cancer metastasis; drug metabolizing; metabolizing enzymes; drug ... See more keywords
Integrative analysis of significant RNA‐binding proteins in colorectal cancer metastasis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27290
Abstract: The aberrant expression of RNA‐binding proteins (RBPs) plays a crucial role in the occurrence and progression of human cancer. However, the key functions of RBPs in the metastasis of colorectal cancer have not yet been… read more here.
Keywords: analysis; cancer metastasis; colorectal cancer; rna ... See more keywords
A Group of miRNA as Candidates for Prognostic Biomarkers of Gastric Cancer Metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-020-04828-3
Abstract: An association was found between reduced expression of miR-34a, miR-146a with both metastasis to regional lymph nodes (relative risk RR=10.50 and RR=5.25, respectively) and the development of distant metastases (RR=9.50 and RR=4, 40, respectively) in… read more here.
Keywords: gastric cancer; cancer metastasis; mir; group ... See more keywords
Platelet “first responders” in wound response, cancer, and metastasis
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DOI: 10.1007/s10555-017-9682-0
Abstract: Platelets serve as “first responders” during normal wounding and homeostasis. Arising from bone marrow stem cell lineage megakaryocytes, anucleate platelets can influence inflammation and immune regulation. Biophysically, platelets are optimized due to size and discoid… read more here.
Keywords: platelet first; cancer metastasis; first responders; cancer ... See more keywords
Unraveling mucin domains in cancer and metastasis: when protectors become predators
Sign Up to like & getrecommendations! Published in 2020 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-020-09896-5
Abstract: A dynamic mucosal layer shields the epithelial cells lining the body cavities and is made up of high molecular weight, heavily glycosylated, multidomain proteins called mucins. Mucins, broadly grouped into transmembrane and secreted mucins, are… read more here.
Keywords: mucin domains; cancer metastasis; unraveling mucin; domain ... See more keywords
Nerve growth factor orchestrates NGAL and matrix metalloproteinases activity to promote colorectal cancer metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02666-x
Abstract: Colorectal cancer (CRC) is one most cancer type of high incidence and high mortality rate. Metastasis play an important role in survival rate and life quality of colorectal cancer patients. Nerve growth factor (NGF) has… read more here.
Keywords: nerve growth; cancer metastasis; colorectal cancer; cancer ... See more keywords