Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.001
Abstract: In this study, we investigated the anticancer efficacy of pegylated liposomes containing 6BrCaQ, an hsp90 inhibitor derived from novobiocin. 6BrCaQ has been previously identified as the most potent compound in a series of quinoleic novobiocin… read more here.
Keywords: cancer; antitumor activity; cancer model; breast cancer ... See more keywords
IL-11 Contribution to Tumorigenesis in an NRF2 Addiction Cancer Model
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.143
Abstract: The KEAP1-NRF2 system, originally identified as a critical defense mechanism against oxidative stress, is often dysregulated in various human cancers forming solid tumors, resulting in the aberrant activation of NRF2. Increased accumulation of NRF2 in… read more here.
Keywords: cancer; tumorigenesis; cancer model; nrf2 addiction ... See more keywords
Chemoradiotherapy screening in a novel biomimetic polymer based pancreatic cancer model
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra09123h
Abstract: Poly-urethane scaffold based 3D pancreatic cancer model enables realistic long term chemotherapy and radiotherapy screening. This model can be used for personalised treatment screening. read more here.
Keywords: chemoradiotherapy screening; cancer model; pancreatic cancer; model ... See more keywords
Optimizing the performance of 68Ga labeled FSHR ligand in prostate cancer model by co-administration of aprotinin
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2022.2063431
Abstract: Abstract Purpose Radiolabeled FSH1 peptides are potential specific probes for FSHR imaging. However, moderate uptakes and fast washout from the tumors may limit its widespread use. In this study, 68Ga labeled modified FSH1 analogs was… read more here.
Keywords: 68ga labeled; prostate cancer; administration; cancer model ... See more keywords
Enhanced biological activity of liposomal methylated resveratrol analog 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) in 3D patient-derived ovarian cancer model
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2103210
Abstract: Abstract 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) belongs to methoxystilbenes family and is an active metabolite of 3,4,5,4′-tetramethoxystilbene (DMU-212). In several of our previous studies, the anti-apoptotic activity of DMU-214 was significantly higher than that of the parent compound,… read more here.
Keywords: ovarian cancer; dmu 214; activity; cancer model ... See more keywords
Establishment of a Human Breast Cancer Model by Fusion PCR for In Vivo and In Vitro Fluorescence Imaging of Human Breast Cancer
Sign Up to like & getrecommendations! Published in 2017 at "DNA and Cell Biology"
DOI: 10.1089/dna.2016.3531
Abstract: This study aimed to construct a breast cancer model that could continuously express the genes of luciferase and green fluorescent protein. The genes luciferase, EGFP, and Neo were obtained by fusion polymerase chain reaction (PCR)… read more here.
Keywords: human breast; cancer model; breast cancer; cancer ... See more keywords
Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-1666
Abstract: These findings uncover differences in nucleotide salvage and de novo biosynthesis using a histologically heterogeneous breast cancer model, highlighting metabolic vulnerabilities in these pathways as promising targets for breast cancer subtypes. Investigating metabolic rewiring in… read more here.
Keywords: breast cancer; tumor growth; cancer; cancer model ... See more keywords
Mathematical analysis of a cancer model with time-delay in tumor-immune interaction and stimulation processes
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Difference Equations"
DOI: 10.1186/s13662-021-03621-4
Abstract: In this study, we discuss a cancer model considering discrete time-delay in tumor-immune interaction and stimulation processes. This study aims to analyze and observe the dynamics of the model along with variation of vital parameters… read more here.
Keywords: time delay; model; cancer model; tumor immune ... See more keywords
Critical evaluation of an autologous peripheral blood mononuclear cell-based humanized cancer model
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0273076
Abstract: The use of humanized mouse models for oncology is rapidly expanding. Autologous patient-derived systems are particularly attractive as they can model the human cancer’s heterogeneity and immune microenvironment. In this study, we developed an autologous… read more here.
Keywords: blood mononuclear; patient derived; peripheral blood; cancer model ... See more keywords
Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20936
Abstract: Clinical trials are studying the benefits of combining the PARP-1 inhibitor olaparib with chemotherapy and radiotherapy treatment in a variety of cancer increasing the therapeutic ratio for olaparib may come from its ability to modify… read more here.
Keywords: cancer; homologous recombination; cancer model; breast cancer ... See more keywords
19F MRI in orthotopic cancer model via intratracheal administration of ανβ3-targeted perfluorocarbon nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Nanomedicine"
DOI: 10.2217/nnm-2018-0051
Abstract: AIM To demonstrate the feasibility of intratracheal administration in orthotopic lung cancer model with 19F MRI. MATERIALS & METHODS αvβ3-integrin targeting ability of the perfluorocarbon (PFC) nanoparticles was tested. Orthotopic lung cancer model was established… read more here.
Keywords: administration; intratracheal administration; cancer model; 19f mri ... See more keywords