Elastin-like Recombinamer Hydrogels as Platforms for Breast Cancer Modeling.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c01080
Abstract: The involvement of the extracellular matrix (ECM) in tumor progression has motivated the development of biomaterials mimicking the tumor ECM to develop more predictive cancer models. Particularly, polypeptides based on elastin could be an interesting… read more here.
Keywords: cancer modeling; like recombinamer; elastin like; breast cancer ... See more keywords
Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade0059
Abstract: CRISPR-Cas9 has been used successfully to introduce indels in somatic cells of rodents; however, precise editing of single nucleotides has been hampered by limitations of flexibility and efficiency. Here, we report technological modifications to the… read more here.
Keywords: crispr cas9; efficient cancer; modeling crispr; cancer modeling ... See more keywords
CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0627-9
Abstract: CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is well-established, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gene knock-in. Here we developed CRISPR-based… read more here.
Keywords: somatic oncogene; knock; crispr; cancer modeling ... See more keywords
Recent Advances of Organ-on-a-Chip in Cancer Modeling Research
Sign Up to like & getrecommendations! Published in 2022 at "Biosensors"
DOI: 10.3390/bios12111045
Abstract: Although many studies have focused on oncology and therapeutics in cancer, cancer remains one of the leading causes of death worldwide. Due to the unclear molecular mechanism and complex in vivo microenvironment of tumors, it… read more here.
Keywords: oncology; cancer; cancer modeling; organ chip ... See more keywords
Histopathological Imaging–Environment Interactions in Cancer Modeling
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11040579
Abstract: Histopathological imaging has been routinely conducted in cancer diagnosis and recently used for modeling other cancer outcomes/phenotypes such as prognosis. Clinical/environmental factors have long been extensively used in cancer modeling. However, there is still a… read more here.
Keywords: clinical environmental; cancer modeling; histopathological imaging; cancer ... See more keywords
Current Advances in 3D Bioprinting for Cancer Modeling and Personalized Medicine
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073432
Abstract: Tumor cells evolve in a complex and heterogeneous environment composed of different cell types and an extracellular matrix. Current 2D culture methods are very limited in their ability to mimic the cancer cell environment. In… read more here.
Keywords: medicine; advances bioprinting; cancer modeling; current advances ... See more keywords
3D bioprinting as an emerging standard for cancer modeling and drug testing.
Sign Up to like & getrecommendations! Published in 2022 at "Folia medica"
DOI: 10.3897/folmed.64.e73419
Abstract: Neoplastic diseases are a leading cause of death worldwide accounting for 10 million mortalities in 2020. Despite constantly revised and improved therapeutic regimens, the number of fatal cases increases annually. Therefore, better preclinical models are… read more here.
Keywords: cancer modeling; standard cancer; emerging standard; tumor ... See more keywords