Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202503104
Abstract: Engineered in vitro cancer models are essential tools in cancer research, offering controlled microenvironments to study tumor biology and develop personalized therapies. Breast cancer, known for its complexity and high cellular heterogeneity, poses significant challenges… read more here.
Keywords: oncology; cancer; breast cancer; engineering ... See more keywords
Assessing the Combinatorial Chemo‐Photothermal Therapy Mediated by Sulfobetaine Methacrylate‐Functionalized Nanoparticles in 2D and 3D In Vitro Cancer Models
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Journal"
DOI: 10.1002/biot.202000219
Abstract: Combinatorial cancer therapies mediated by nanomaterials can potentially overcome the limitations of conventional treatments. These therapies are generally investigated using 2D in vitro cancer models, leading to an inaccurate screening. Recently, 3D in vitro spheroids… read more here.
Keywords: cancer; photothermal therapy; chemo photothermal; cancer models ... See more keywords
Physical exercise effects on metastasis: a systematic review and meta-analysis in animal cancer models
Sign Up to like & getrecommendations! Published in 2020 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-020-09851-4
Abstract: Physical exercise is considered a well-tolerated adjuvant therapy to mitigate cancer-related side effects, but its impact on metastasis is unclear. The present systematic review and meta-analysis aimed to summarize the evidence on the effects of… read more here.
Keywords: systematic review; metastasis; cancer; exercise ... See more keywords
Current status and perspectives of patient-derived rare cancer models
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DOI: 10.1007/s13577-020-00391-1
Abstract: Malignancies with extremely low incidences, such as less than 6 per 100,000 people annually, are defined as rare cancers. Approximately 200 malignancies are classified in this category, therefore the total number of patients with rare… read more here.
Keywords: rare cancer; rare cancers; derived rare; cancer ... See more keywords
Blockade of TGF-β and PD-L1 by bintrafusp alfa promotes survival in preclinical ovarian cancer models by promoting T effector and NK cell responses
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Cancer"
DOI: 10.1038/s41416-024-02677-9
Abstract: Failure of immunotherapy in high-grade serous ovarian cancer (HGSC) may be due to high levels of transforming growth factor-β (TGF-β) in ascites or tumour immune microenvironment (TIME). Here, we test whether coordinated blockade of TGF-β… read more here.
Keywords: cancer; tgf bintrafusp; blockade tgf; ovarian cancer ... See more keywords
Executable cancer models: successes and challenges
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Cancer"
DOI: 10.1038/s41568-020-0258-x
Abstract: Making decisions on how best to treat cancer patients requires the integration of different data sets, including genomic profiles, tumour histopathology, radiological images, proteomic analysis and more. This wealth of biological information calls for novel… read more here.
Keywords: executable cancer; models successes; cancer; successes challenges ... See more keywords
Multi-colour extrusion fused deposition modelling: a low-cost 3D printing method for anatomical prostate cancer models
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67082-7
Abstract: Three-dimensional (3D) printed prostate cancer models are an emerging adjunct for urological surgical planning and patient education, however published methods are costly which limits their translation into clinical practice. Multi-colour extrusion fused deposition modelling (FDM)… read more here.
Keywords: prostate; method; prostate cancer; cost ... See more keywords
Modulating cell differentiation in cancer models.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society transactions"
DOI: 10.1042/bst20210230
Abstract: Cancer has been traditionally viewed as a disease characterised by excessive and uncontrolled proliferation, leading to the development of cytotoxic therapies against highly proliferating malignant cells. However, tumours frequently relapse due to the presence of… read more here.
Keywords: differentiation; cell differentiation; cancer; cancer models ... See more keywords
Radiosensitizing Potential of Curcumin in Different Cancer Models
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2019.1681480
Abstract: Abstract Over the past decades, studies of phytochemicals as modifiers of radiotherapeutic efficacy have become increasingly popular to improve the treatment outcome of human malignancies. In the current comprehensive review article, radiosensitizing effects of curcumin,… read more here.
Keywords: squamous cell; cancer; factor; cell ... See more keywords
Anti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer models
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DOI: 10.1080/19420862.2021.1914883
Abstract: ABSTRACT Chemoresistance, particularly to gemcitabine, is a major challenge in pancreatic cancer. The epidermal growth factor receptor (EGFR) and human epidermal growth factor receptors 2 and 3 (HER2, HER3) are expressed in many tumors, and… read more here.
Keywords: gemcitabine; resistant pancreatic; pancreatic cancer; cancer models ... See more keywords
Ultrasound molecular imaging of the secreted tumor marker Netrin-1 in multiple breast cancer models
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Acoustical Society of America"
DOI: 10.1121/1.5014373
Abstract: With regard to biomarker expression, tumors are heterogeneous media displaying intra- and interpatient variability. Ultrasound molecular imaging (USMI) is a newly developed tool that can characterize heterogeneous tumors. Here, we focus on Netrin-1-overexpressing breast cancer.… read more here.
Keywords: breast; breast cancer; ultrasound molecular; molecular imaging ... See more keywords