Cancer Mutations in SPOP Put a Stop to Its Inter-compartmental Hops.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.09.025
Abstract: In this issue of Molecular Cell, Bouchard et al. (2018) identify liquid-liquid phase separation as a mechanism for substrate-triggered localization of SPOP and ubiquitination machinery to different nuclear bodies and describe how cancer mutations disrupt this… read more here.
Keywords: cancer mutations; mutations spop; put stop; spop put ... See more keywords
The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19221-x
Abstract: The ASCC3 subunit of the activating signal co-integrator complex is a dual-cassette Ski2-like nucleic acid helicase that provides single-stranded DNA for alkylation damage repair by the α-ketoglutarate-dependent dioxygenase AlkBH3. Other ASCC components integrate ASCC3/AlkBH3 into… read more here.
Keywords: cancer mutations; affected somatic; dna repair; ascc2 ascc3 ... See more keywords
Using CRISPR to understand how cancer mutations happen
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02313-9
Abstract: Somatic mutations in cancer genomes can be caused by many different mutational processes, each of which produce distinctive patterns termed “mutational signatures”. Although cancer researchers can now recognize a large number of mutational signatures, exactly… read more here.
Keywords: cancer mutations; mutations happen; crispr understand; understand cancer ... See more keywords
Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.
Sign Up to like & getrecommendations! Published in 2023 at "Veterinary and comparative oncology"
DOI: 10.1111/vco.12911
Abstract: The accrual of cancer mutation data and related functional and clinical associations have revolutionised human oncology, enabling the advancement of precision medicine and biomarker-guided clinical management. The catalogue of cancer mutations is also growing in… read more here.
Keywords: oncology; cancer mutations; canine; precision medicine ... See more keywords
Modeling Cancer Mutations in 3-D.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2017-091
Abstract: Researchers from the Wellcome Trust Sanger Institute have launched COSMIC-3D, a tool that allows scientists to explore how cancer mutations affect the structure and function of more than 8,000 human proteins. They hope COSMIC-3D, which… read more here.
Keywords: cancer; cancer mutations; modeling cancer;
Examining Sporadic Cancer Mutations Uncovers a Set of Genes Involved in Mitochondrial Maintenance
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14051009
Abstract: Mitochondria are key organelles for cellular health and metabolism and the activation of programmed cell death processes. Although pathways for regulating and re-establishing mitochondrial homeostasis have been identified over the past twenty years, the consequences… read more here.
Keywords: examining sporadic; cancer mutations; sporadic cancer; cancer ... See more keywords