Identification of alternative splicing-derived cancer neoantigens for mRNA vaccine development
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab553
Abstract: Messenger RNA (mRNA) vaccines have shown great potential for anti-tumor therapy due to the advantages in safety, efficacy and industrial production. However, it remains a challenge to identify suitable cancer neoantigens that can be targeted… read more here.
Keywords: derived cancer; alternative splicing; cancer neoantigens; splicing derived ... See more keywords
Cancer Neoantigens.
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-042617-053402
Abstract: Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell-based immune system frequently responds to the neoantigens that arise as a consequence of this… read more here.
Keywords: cancer; cancer neoantigens; cell; immunology ... See more keywords
Mitochondrial Proteins as Source of Cancer Neoantigens
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DOI: 10.3390/ijms23052627
Abstract: In the past decade, anti-tumour immune responses have been successfully exploited to improve the outcome of patients with different cancers. Significant progress has been made in taking advantage of different types of T cell functions… read more here.
Keywords: cancer; mitochondrial proteins; source cancer; proteins source ... See more keywords
Sources of Cancer Neoantigens beyond Single-Nucleotide Variants
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DOI: 10.3390/ijms231710131
Abstract: The success of checkpoint blockade therapy against cancer has unequivocally shown that cancer cells can be effectively recognized by the immune system and eliminated. However, the identity of the cancer antigens that elicit protective immunity… read more here.
Keywords: nucleotide variants; neoantigens beyond; single nucleotide; cancer neoantigens ... See more keywords