From organoids to bedside: Advances in modeling, decoding and targeting of colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34297
Abstract: Patient derived organoids closely resemble the biology of tissues and tumors. They are enabling ex vivo modeling of human diseases and dissecting key features of tumor biology like anatomical diversity or inter‐ and intra‐tumoral heterogeneity.… read more here.
Keywords: biology; cancer organoids; bedside advances; colorectal cancer ... See more keywords
A biobank for bladder cancer
Sign Up to like & getrecommendations! Published in 2018 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0114-3
Abstract: Diverse clinical outcomes in bladder cancers result from varying molecular profiles. Shen and colleagues generated a biobank of patient-derived bladder cancer organoids to study tumour heterogeneity, evolution and drug responses. Organoid lines were established from… read more here.
Keywords: bladder cancer; mutational profiles; biobank bladder; cancer organoids ... See more keywords
Patient‐derived cancer organoids for drug screening: Basic technology and clinical application
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.15930
Abstract: Cancer organoids, a three‐dimensional (3D) culture system of cancer cells derived from tumor tissues, recapitulate physiological structure of the parental tumor. Different tumor organoids have been established for a variety of tumor types, such as… read more here.
Keywords: application; drug screening; cancer organoids; tumor ... See more keywords
Cancer organoids to model therapy response
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.359.6378.880-d
Abstract: Organoids Cancer organoids are miniature, three-dimensional cell culture models that can be made from primary patient tumors and studied in the laboratory. Vlachogiannis et al. asked whether such “tumor-in-a-dish” approaches can be used to predict… read more here.
Keywords: drug; therapy response; cancer organoids; model therapy ... See more keywords
Human gastric cancer modelling using organoids
Sign Up to like & getrecommendations! Published in 2019 at "Gut"
DOI: 10.1136/gutjnl-2017-314549
Abstract: Objective Gastric cancer is the second leading cause of cancer-related deaths and the fifth most common malignancy worldwide. In this study, human and mouse gastric cancer organoids were generated to model the disease and perform… read more here.
Keywords: mouse gastric; gastric cancer; cancer organoid; cancer organoids ... See more keywords
EP1118 Patient-derived ovarian cancer organoids resemble clinical response to chemotherapeutics and provide insights into response mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-esgo.1160
Abstract: Introduction/Background Epithelial ovarian cancer is characterized by intratumour genetic heterogeneity, chemotherapy resistance and poor survival. The advent of ovarian cancer organoids, that recapitulate histological and genetic features of the original lesions, has providedopportunities for personalized… read more here.
Keywords: response; drug response; cancer organoids; ovarian cancer ... See more keywords
Abstract LB236: Utilizing endometrial tumor organoids to model cancer immunomodulation
Sign Up to like & getrecommendations! Published in 2021 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2021-lb236
Abstract: Endometrial cancer is the most common gynecologic malignancy in the United States. Most women present with early stage disease and have a favorable prognosis. However, the treatment options for recurrent endometrial cancer is limited. Immunotherapy… read more here.
Keywords: cancer; model; cancer organoids; tumor ... See more keywords
Abstract 165: Establishment and characterization of Vogelgram-mimic colorectal cancer organoids as a laboratory tool
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-165
Abstract: Colorectal cancer is a deadly disease with a 14% five-year survival rate once it metastasizes. The development of colorectal cancer involves a stepwise accumulation of genetic alterations in APC, KRAS, DCC, and p53 that is… read more here.
Keywords: cancer organoids; colorectal cancer; p53; laboratory tool ... See more keywords
Abstract 200: Patient-derived cervical cancer organoids as a pre-clinical model predicting drug and radiation response
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-200
Abstract: Objective: Advanced cervical cancer is still difficult to treat and in the case of recurrent cancer, it is desirable to utilize personalized treatment rather than uniform treatment because the type of recurrence is different for… read more here.
Keywords: cervical cancer; cancer organoids; patient derived; radiation ... See more keywords
Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models
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DOI: 10.1186/s12885-018-4238-4
Abstract: BackgroundPatient-derived tumor models are the new standard for pre-clinical drug testing and biomarker discovery. However, the emerging technology of primary pancreatic cancer organoids has not yet been broadly implemented in research, and complex organotypic models… read more here.
Keywords: stromal immune; pancreatic cancer; cancer organoids; cancer ... See more keywords
Novel therapeutic strategy to inhibit growth of pancreatic cancer organoids using a rational combination of drugs to induce mitotic arrest and apoptosis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.322
Abstract: 322Background: The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The Bcl-2-family of regulator proteins, including the anti-apoptotic members Bcl-2, Bcl-xL and Mcl-1, contributes to a complex network in control of apoptosis.… read more here.
Keywords: combination; apoptosis; pancreatic cancer; cancer organoids ... See more keywords