Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes
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DOI: 10.1093/molbev/msac084
Abstract: Abstract Mutational processes in tumors create distinctive patterns of mutations, composed of neutral “passenger” mutations and oncogenic drivers that have quantifiable effects on the proliferation and survival of cancer cell lineages. Increases in proliferation and… read more here.
Keywords: cancer origins; mutational processes; attribution cancer; endogenous exogenous ... See more keywords
Predicting cancer origins with a DNA methylation-based deep neural network model
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0226461
Abstract: Cancer origin determination combined with site-specific treatment of metastatic cancer patients is critical to improve patient outcomes. Existing pathology and gene expression-based techniques often have limited performance. In this study, we developed a deep neural… read more here.
Keywords: methylation based; cancer origins; pathology; cancer ... See more keywords