Argininosuccinate Synthase 1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b01158
Abstract: Like many cancer types, colorectal cancers have dysregulated metabolism that promotes their pathogenic features. In this study, we used the activity-based protein profiling chemoproteomic platform to profile cysteine-reactive metabolic enzymes that are upregulated in primary… read more here.
Keywords: cancer; argininosuccinate synthase; colorectal cancer; cancer pathogenicity ... See more keywords
Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc01480e
Abstract: Chemical genetics has arisen as a powerful approach for identifying novel anti-cancer agents. However, a major bottleneck of this approach is identifying the targets of lead compounds that arise from screens. Here, we coupled the… read more here.
Keywords: reticulon; colorectal cancer; pathogenicity; cancer ... See more keywords