Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13817
Abstract: Immune status critically affects cancer progression and therapy responses. This study aimed to identify plasma proteome changes in immunosuppressive cancer and potential biomarkers predicting systemic immunosuppression. Mouse models of syngeneic breast tumors (benign 67NR and… read more here.
Keywords: peripheral blood; cancer; cancer progression; proteome ... See more keywords
Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202407575
Abstract: The immune evasion is one major challenge for cancer immunotherapy. Despite considerable advancements in immune checkpoint blockade (ICB) therapies for the advanced non‐small cell lung cancer (NSCLC) patients, only a minority of patients receive long‐term… read more here.
Keywords: cancer; lung cancer; progression; cancer progression ... See more keywords
TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202512725
Abstract: TRIM38, an E3 ubiquitin-protein ligase, has previously been implicated in innate immune and inflammatory responses, yet its role in breast cancer regulation remains unclear. This study elucidates the suppressive function of TRIM38 in breast cancer… read more here.
Keywords: breast cancer; cancer; autophagic flux; trim38 ... See more keywords
Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000221
Abstract: Adherens (AJ) and tight junctions (TJ) maintain cell‐cell adhesions and cellular polarity in normal tissues. Afadin, a multi‐domain scaffold protein, is commonly found in both adherens and tight junctions, where it plays both structural and… read more here.
Keywords: cancer; scaffold protein; cancer progression; roles afadin ... See more keywords
PRDX6 Drives Breast Cancer Progression Through Mitochondrial Biosynthesis and Oxidative Phosphorylation
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DOI: 10.1002/cam4.71005
Abstract: Peroxiredoxin 6 (PRDX6) scavenges reactive oxygen species (ROS) and plays a key role in antioxidant defense. Although PRDX6 is involved in various cancers, its role in breast cancer (BRCA) remains unclear. read more here.
Keywords: cancer; breast cancer; cancer progression; prdx6 ... See more keywords
MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.7424
Abstract: Gastric cancer (GC) is the fourth leading cause of cancer‐related death worldwide. Minichromsome maintenance proteins family member 8 (MCM8) assists DNA repair and DNA replication. MCM8 exerts tumor promotor function in multiple digestive system tumors.… read more here.
Keywords: cancer; mcm8; promotes gastric; gastric cancer ... See more keywords
End Binding Proteins: Drivers of Cancer Progression
Sign Up to like & getrecommendations! Published in 2024 at "Cytoskeleton"
DOI: 10.1002/cm.21972
Abstract: Cancer, a complex and heterogeneous disease, continues to be a major global health concern. Despite advancements in diagnostics and therapeutics, the aggressive nature of certain cancers remain a significant challenge, necessitating a deeper understanding of… read more here.
Keywords: cancer; progression; cancer progression; binding proteins ... See more keywords
Dietary fat in relation to all‐cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from CALGB 80405 (Alliance)/SWOG 80405
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34230
Abstract: Data on diet and survival among people with metastatic colorectal cancer are limited. We examined dietary fat in relation to all‐cause mortality and cancer progression or death among 1149 people in the Cancer and Leukemia… read more here.
Keywords: mortality; cancer; progression death; cancer progression ... See more keywords
Emerging roles of syndecan 2 in epithelial and mesenchymal cancer progression
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DOI: 10.1002/iub.1678
Abstract: Syndecan 2 (SDC2) belongs to a four‐member family of evolutionary conserved small type I transmembrane proteoglycans consisting of a protein core to which glycosaminoglycan chains are covalently attached. SDC2 is a cell surface heparan sulfate… read more here.
Keywords: sdc2; emerging roles; cancer progression; roles syndecan ... See more keywords
Hyaluronan as “Agent Smith” in cancer extracellular matrix pathobiology: Regulatory roles in immune response, cancer progression and targeting
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DOI: 10.1002/iub.2608
Abstract: Extracellular matrix (ECM) critically regulates cancer cell behavior by governing cell signaling and properties. Hyaluronan (HA) acts as a structural and functional ECM component that mediates critical properties of cancer cells in a molecular size‐dependent… read more here.
Keywords: extracellular matrix; progression; cancer progression; hyaluronan agent ... See more keywords
circPIP5K1A serves as a competitive endogenous RNA contributing to ovarian cancer progression via regulation of miR‐661/IGFBP5 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29055
Abstract: Increasing evidence demonstrates the crucial regulatory functions of circular RNAs in different cancer types. The major aim of the current study was to establish functions of circPIP5K1A during ovarian cancer. Our results showed an increased… read more here.
Keywords: mir 661; circpip5k1a; ovarian cancer; cancer progression ... See more keywords