P‐Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects
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DOI: 10.1002/cpdd.1088
Abstract: Rimegepant (Nurtec ODT)—an orally administered, small‐molecule calcitonin gene–related peptide receptor antagonist indicated for the acute and preventive treatment of migraine—is a substrate for both the P‐glycoprotein and breast cancer resistance protein transporters in vitro. We… read more here.
Keywords: breast cancer; resistance protein; quinidine; cancer resistance ... See more keywords
Clinical Drug‐Drug Interaction Between Vatiquinone, a 15‐Lipoxygenase Inhibitor, and Rosuvastatin, a Breast Cancer Resistance Protein Substrate
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1199
Abstract: Vatiquinone is a small‐molecule inhibitor of 15‐lipoxygenase in phase 3 development for patients with mitochondrial disease and Friedreich ataxia. The objective of this analysis was to determine the effect of vatiquinone on the pharmacokinetic profile… read more here.
Keywords: rosuvastatin breast; breast cancer; cancer resistance; drug ... See more keywords
Identification and Clinical Evaluation of Potential Biomarkers for Breast Cancer Resistance Protein (BCRP/ ABCG2 )
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DOI: 10.1002/cpt.3657
Abstract: Clinical inhibition and genetic variation of the Breast Cancer Resistance Protein (BCRP/ABCG2) efflux transporter can significantly influence drug exposure, highlighting the need for reliable BCRP functional biomarkers. This study aimed to identify and evaluate biomarkers… read more here.
Keywords: breast cancer; bcrp; function; cancer resistance ... See more keywords
Fighting Cancer Resistance: An Overview.
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DOI: 10.1007/978-1-0716-0759-6_1
Abstract: The inherent or developed resistance of many cancer cells to chemotherapy and irradiation is actually the main challenge to overcome in cancer treatment. It is well known that cancer cells are characterized by several hallmarks,… read more here.
Keywords: cancer resistance; fighting cancer; resistance; resistance overview ... See more keywords
Inhibition of Breast Cancer Resistance Protein (BCRP) by Ko143 Can Affect Pharmacokinetics of Enrofloxacin in Exopalaemon carinicauda
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DOI: 10.1007/s11802-020-4312-9
Abstract: Adenosine triphosphate-binding cassette transporter breast cancer resistance protein (BCRP) exists highly in the apical membranes of epithelia, and is involved in drug availability. Ko143 is a typical inhibitor of BCRP in rodents. The synthetic antibacterial… read more here.
Keywords: cancer resistance; resistance protein; breast cancer; exopalaemon carinicauda ... See more keywords
Overcoming resistance to targeted therapy using MET inhibitors in solid cancers: evidence from preclinical and clinical studies
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DOI: 10.1007/s12032-021-01596-6
Abstract: Targeted therapy is a hallmark of cancer treatment that has changed the landscape of cancer management and enabled a personalized treatment approach. Nevertheless, the development of cancer resistance is a major challenge that is currently… read more here.
Keywords: cancer resistance; targeted therapy; evidence; resistance ... See more keywords
Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113017
Abstract: Multidrug resistance membrane pumps reduce the efficacy of chemotherapies by exporting a wide panel of structurally-divergent drugs. Here, to take advantage of the polyspecificity of the human Breast Cancer Resistance Protein (BCRP/ABCG2) and the dimeric… read more here.
Keywords: human breast; cancer resistance; breast cancer; resistance ... See more keywords
Correlation Analysis of Potential Breast Cancer Resistance Protein Probes in Different Monolayer Systems.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.07.014
Abstract: Breast cancer resistance protein (BCRP) is a point of interest in drug-drug interaction safety testing. Therefore, a consensus probe that can be applied as victim in multiple experimental settings is of great benefit. Identification of… read more here.
Keywords: resistance protein; cancer resistance; breast cancer;
Characterization of an active LINE-1 in the naked mole-rat genome
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DOI: 10.1038/s41598-021-84962-8
Abstract: Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-living rodent species. A reason for their long lifespan is pronounced cancer resistance. Therefore, researchers believe that NMRs have unknown secrets of cancer resistance and seek to find… read more here.
Keywords: nmr genome; cancer resistance; naked mole; retrotransposition ... See more keywords
Inhibition of breast cancer resistance protein by flavonols: in vitro, in vivo, and in silico implications of the interactions
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DOI: 10.1038/s41598-025-13908-1
Abstract: Breast cancer resistance protein (BCRP), a member of the ATP-binding cassette transporter family, plays a key role in the efflux of various drugs and is linked to multidrug resistance in cancer therapy. Flavonoids, particularly those… read more here.
Keywords: cancer; resistance; breast cancer; cancer resistance ... See more keywords
Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats
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DOI: 10.1080/00498254.2021.2025281
Abstract: Abstract Breast cancer resistance protein (BCRP/Abcg2 in human, Bcrp/Abcg2 in rat), a member of the ATP-binding cassette (ABC) transporter family, acts as an efflux pump for xenobiotics, with ability to transport various drugs out of… read more here.
Keywords: protein bcrp; breast cancer; bcrp abcg2; cancer resistance ... See more keywords