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Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1088
Abstract: Rimegepant (Nurtec ODT)—an orally administered, small‐molecule calcitonin gene–related peptide receptor antagonist indicated for the acute and preventive treatment of migraine—is a substrate for both the P‐glycoprotein and breast cancer resistance protein transporters in vitro. We…
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Keywords:
breast cancer;
resistance protein;
quinidine;
cancer resistance ... See more keywords
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Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1199
Abstract: Vatiquinone is a small‐molecule inhibitor of 15‐lipoxygenase in phase 3 development for patients with mitochondrial disease and Friedreich ataxia. The objective of this analysis was to determine the effect of vatiquinone on the pharmacokinetic profile…
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Keywords:
rosuvastatin breast;
breast cancer;
cancer resistance;
drug ... See more keywords
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Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0759-6_1
Abstract: The inherent or developed resistance of many cancer cells to chemotherapy and irradiation is actually the main challenge to overcome in cancer treatment. It is well known that cancer cells are characterized by several hallmarks,…
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Keywords:
cancer resistance;
fighting cancer;
resistance;
resistance overview ... See more keywords
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Published in 2020 at "Journal of Ocean University of China"
DOI: 10.1007/s11802-020-4312-9
Abstract: Adenosine triphosphate-binding cassette transporter breast cancer resistance protein (BCRP) exists highly in the apical membranes of epithelia, and is involved in drug availability. Ko143 is a typical inhibitor of BCRP in rodents. The synthetic antibacterial…
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Keywords:
cancer resistance;
resistance protein;
breast cancer;
exopalaemon carinicauda ... See more keywords
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Published in 2021 at "Medical Oncology"
DOI: 10.1007/s12032-021-01596-6
Abstract: Targeted therapy is a hallmark of cancer treatment that has changed the landscape of cancer management and enabled a personalized treatment approach. Nevertheless, the development of cancer resistance is a major challenge that is currently…
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Keywords:
cancer resistance;
targeted therapy;
evidence;
resistance ... See more keywords
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Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113017
Abstract: Multidrug resistance membrane pumps reduce the efficacy of chemotherapies by exporting a wide panel of structurally-divergent drugs. Here, to take advantage of the polyspecificity of the human Breast Cancer Resistance Protein (BCRP/ABCG2) and the dimeric…
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Keywords:
human breast;
cancer resistance;
breast cancer;
resistance ... See more keywords
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Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.07.014
Abstract: Breast cancer resistance protein (BCRP) is a point of interest in drug-drug interaction safety testing. Therefore, a consensus probe that can be applied as victim in multiple experimental settings is of great benefit. Identification of…
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Keywords:
resistance protein;
cancer resistance;
breast cancer;
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Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84962-8
Abstract: Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-living rodent species. A reason for their long lifespan is pronounced cancer resistance. Therefore, researchers believe that NMRs have unknown secrets of cancer resistance and seek to find…
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Keywords:
nmr genome;
cancer resistance;
naked mole;
retrotransposition ... See more keywords
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Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2021.2025281
Abstract: Abstract Breast cancer resistance protein (BCRP/Abcg2 in human, Bcrp/Abcg2 in rat), a member of the ATP-binding cassette (ABC) transporter family, acts as an efflux pump for xenobiotics, with ability to transport various drugs out of…
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Keywords:
protein bcrp;
breast cancer;
bcrp abcg2;
cancer resistance ... See more keywords
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Published in 2020 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13225
Abstract: Ezrin (Ezr), radixin (Rdx) and moesin (Msn) (ERM) proteins anchor other proteins to the cell membrane, serving to regulate their localization and function. Here, we examined whether ERM proteins functionally regulate breast cancer resistance protein…
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Keywords:
cancer resistance;
resistance protein;
cell lines;
lung intestinal ... See more keywords
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Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003760
Abstract: The tumor microenvironment (TME) is characterized by the activation of immune checkpoints, which limit the ability of immune cells to attack the growing cancer. To overcome immune suppression in the clinic, antigen-expressing viruses and bacteria…
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Keywords:
therapy remodeling;
tumor microenvironment;
live attenuated;
cancer resistance ... See more keywords