Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance
Sign Up to like & getrecommendations! Published in 2018 at "Essays in Biochemistry"
DOI: 10.1042/ebc20180016
Abstract: Drug resistance remains one of the greatest challenges facing precision oncology today. Despite the vast array of resistance mechanisms that cancer cells employ to subvert the effects of targeted therapy, a deep understanding of cancer… read more here.
Keywords: cancer signalling; targeted therapy; resistance; cancer ... See more keywords
Application of Atlas of Cancer Signalling Network in preclinical studies
Sign Up to like & getrecommendations! Published in 2019 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bby031
Abstract: Cancer initiation and progression are associated with multiple molecular mechanisms. The knowledge of these mechanisms is expanding and should be converted into guidelines for tackling the disease. Here, we discuss the formalization of biological knowledge… read more here.
Keywords: network; cancer signalling; atlas cancer; omics data ... See more keywords