Hypoxia‐inducible factor‐2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12419
Abstract: Ovarian cancer stem cells (OCSCs) are sources of tumor chemoresistance and recurrence. A hypoxic microenvironment contributes to the chemoresistance of cancer stem cells (CSCs), but the underlying mechanism is not fully understood yet. Here, we… read more here.
Keywords: hif; cancer stem; resistance; expression ... See more keywords
A new protocol for long‐term culture of a specific subpopulation of liver cancer stem cells enriched by cell surface markers
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12932
Abstract: Liver cancer stem cells (L‐CSCs) are considered to be an important therapeutic target for hepatocellular carcinoma (HCC). This study provides a new in vitro long‐term culture model for a specific subpopulation of L‐CSCs enriched by… read more here.
Keywords: long term; cancer stem; surface markers;
The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13207
Abstract: Mitophagy, a form of autophagy, plays a role in cancer development, progression and recurrence. Cancer stem cells (CSCs) also play a key role in these processes, although it not known whether mitophagy can regulate the… read more here.
Keywords: cancer stem; mitochondrial fission; cancer; fis1 ... See more keywords
ARL2 is required for homologous recombination repair and colon cancer stem cell survival
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DOI: 10.1002/2211-5463.13438
Abstract: ARL2 regulates the dynamics of cytological components and is highly expressed in colon cancer tissues. Here, we report novel roles of ARL2 in the cell nucleus and colon cancer stem cells (CSCs). ARL2 is expressed… read more here.
Keywords: arl2; cancer stem; colon cancer; colon ... See more keywords
A curcumin analogue GO‐Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13550
Abstract: Cancer stem cells (CSCs) are proposed to be involved in tumor initiation and play important roles in cancer relapse, metastasis, and drug resistance. Therefore, the targeting of CSCs has potential for effective anticancer therapies. Curcumin… read more here.
Keywords: cancer stem; hsp40; y030; hsp70 hsp40 ... See more keywords
Bioinspired One Cell Culture Isolates Highly Tumorigenic and Metastatic Cancer Stem Cells Capable of Multilineage Differentiation
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DOI: 10.1002/advs.202000259
Abstract: Abstract Cancer stem cells (CSCs) are rare cancer cells that are postulated to be responsible for cancer relapse and metastasis. However, CSCs are difficult to isolate and poorly understood. Here, a bioinspired approach for label‐free… read more here.
Keywords: stem cells; cancer stem; cells capable; cancer ... See more keywords
A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer
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DOI: 10.1002/advs.202201166
Abstract: Cancer stem cells (CSCs) are reported to play essential roles in chemoresistance and metastasis. Pathways regulating CSC self‐renewal and proliferation, such as Hedgehog, Notch, Wnt/β‐catenin, TGF‐β, and Myc, may be potential therapeutic targets. Here, a… read more here.
Keywords: inhibition; transcription; cancer stem; functional screening ... See more keywords
Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation
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DOI: 10.1002/advs.202203173
Abstract: A recently developed synthetic retinoid abrogates proliferation and induces apoptosis of drug‐resistant malignant‐cancer‐stem‐cell‐like cells. However, the underlying mechanisms of how the synthetic retinoid induces cancer‐stem‐cell‐like cell tumor‐repopulating cell (TRC) apoptosis are elusive. Here, it is… read more here.
Keywords: cancer stem; synthetic retinoid; tension; retinoid ... See more keywords
Diphenyleneiodonium efficiently inhibits the characteristics of a cancer stem cell model derived from induced pluripotent stem cells
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DOI: 10.1002/cbf.3696
Abstract: Diphenyleneiodonium (DPI) has long been evaluated as an anticancer drug inhibiting NADPH oxidase, the IC50 in several cancer cell lines was reported 10 µM, which is too high for efficacy. In this study, we employed miPS‐Huh7cmP… read more here.
Keywords: stem cell; pluripotent stem; cancer stem; induced pluripotent ... See more keywords
Substituted chloroacetamides as potential cancer stem cell inhibitors: Synthesis and biological evaluation
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DOI: 10.1002/ddr.21628
Abstract: Cancer kills, irrespective of geographical and cultural origin. Novel modalities for treating cancer are desperately needed. Cancer stem cells (CSCs), main culprits behind chemoresistance and tumor relapse, are one of the few logical choices. Herein,… read more here.
Keywords: cancer stem; biological evaluation; cancer; cell ... See more keywords
A novel series of substituted 1,2,3‐triazoles as cancer stem cell inhibitors: Synthesis and biological evaluation
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DOI: 10.1002/ddr.21723
Abstract: An alarming increase in global death toll resulting from cancer incidents, particularly due to multidrug resistance and reduced efficacy as a consequence of target mutations, has compelled us to look for novel anticancer agents. Cancer… read more here.
Keywords: cancer stem; novel series; series; cancer ... See more keywords