Autophagy inhibits cancer stemness in triple‐negative breast cancer via miR‐181a‐mediated regulation of ATG5 and/or ATG2B
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13180
Abstract: Autophagy has a dual role in the maintenance of cancer stem cells (CSCs), but the precise relationship between autophagy and cancer stemness requires further investigation. In this study, it was found that luminal and triple‐negative… read more here.
Keywords: mir 181a; triple negative; cancer stemness; cancer ... See more keywords
Long non‐coding RNA TDRG1 aggravates lung cancer stemness by binding to Sox2 mRNA
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23714
Abstract: The roles of long non‐coding RNA TDRG1 have been revealed in several tumors, especially its roles in CSC progression have been recently elucidated; However, its effects in lung CSC progression have not been revealed. In… read more here.
Keywords: lung; lung cancer; cancer stemness; tdrg1 ... See more keywords
Erianin suppressed lung cancer stemness and chemotherapeutic sensitivity via triggering ferroptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23832
Abstract: The previous research has focused on the suppressive effects of Erianin on tumor progression, but its impact on cancer stemness has not been reported. This study aimed to investigate the effects of Erianin on lung… read more here.
Keywords: lung cancer; cancer stemness; ferroptosis; cancer ... See more keywords
Steroidal saponins from Trillium tschonoskii rhizome repress cancer stemness and proliferation of intrahepatic cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105679
Abstract: A phytochemical study was carried out on the extract of Trillium tschonoskii rhizomes, resulting in the isolation of thirty-six steroidal glycosides (1-36). Their structures were established mainly by spectroscopic analyses as well as necessary chemical… read more here.
Keywords: repress cancer; trillium tschonoskii; intrahepatic cholangiocarcinoma; cancer stemness ... See more keywords
Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2021.12.005
Abstract: BACKGROUND & AIMS Extracellular vesicles (EVs) play a pivotal role in connecting tumor cells and their local and distant microenvironments. Here, we aimed to understand the role and molecular basis of patient-derived EVs in modulating… read more here.
Keywords: cancer; pigr; hcc; stemness tumorigenesis ... See more keywords
Targeting Cancer Stemness in the Clinic: From Hype to Hope.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2018.11.017
Abstract: Tumors are composed of non-homogeneous cell populations exhibiting varying degrees of genetic and functional heterogeneity. Cancer stem cells (CSCs) are capable of sustaining tumors by manipulating genetic and non-genetic factors to metastasize, resist treatment, and… read more here.
Keywords: targeting cancer; cancer stemness; clinic hype; stemness clinic ... See more keywords
QAP14 suppresses breast cancer stemness and metastasis via activation of dopamine D1 receptor.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00701-9
Abstract: Breast cancer is the second leading cause of cancer-related mortality in women, mainly due to metastasis, which is strongly associated with cancer stemness. Our previous studies showed that the eradication of cancer stem-like cells (CSCs)… read more here.
Keywords: breast cancer; metastasis; d1dr; cancer stemness ... See more keywords
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13700-6
Abstract: The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may ameliorate breast cancer relapse and therapy resistance. Here we report that… read more here.
Keywords: cancer; degradation; cancer stemness; breast cancer ... See more keywords
Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17768-3
Abstract: Strategies for eradicating cancer stem cells (CSCs) are urgently required because CSCs are resistant to anticancer drugs and cause treatment failure, relapse and metastasis. Here, we show that photoactive functional nanocarbon complexes exhibit unique characteristics,… read more here.
Keywords: cancer; near infrared; inhibition cancer; cancer stemness ... See more keywords
WNT signaling and cancer stemness
Sign Up to like & getrecommendations! Published in 2022 at "Essays in Biochemistry"
DOI: 10.1042/ebc20220016
Abstract: Abstract Cancer stemness, defined as the self-renewal and tumor-initiation potential of cancer stem cells (CSCs), is a cancer biology property featuring activation of CSC signaling networks. Canonical WNT signaling through Frizzled and LRP5/6 receptors is… read more here.
Keywords: plasticity; cancer stemness; cancer; wnt signaling ... See more keywords
Targeting cancer stemness mediated by BMI1 and MCL1 for non‐small cell lung cancer treatment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17453
Abstract: Lung cancer is the leading cause of cancer‐associated death, with a global 5‐year survival rate read more here.
Keywords: lung cancer; cancer stemness; cancer; bmi1 mcl1 ... See more keywords