Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2021.6744
Abstract: Key Points Question What breast tumor characteristics are associated with rare pathogenic protein truncating or missense variants in breast cancer susceptibility genes? Findings In this case-control study involving 46 387 control participants and 42 680 women with… read more here.
Keywords: susceptibility genes; pathology; breast cancer; cancer susceptibility ... See more keywords
Inherited Cancer Susceptibility Gene Sequence Variations Among Patients With Appendix Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.5425
Abstract: Importance Germline sequence variations in APC, BMPR1A, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, SMAD4, STK11, and TP53 genes are associated with susceptibility to gastrointestinal cancers. As a rare cancer, the evaluation of… read more here.
Keywords: cancer susceptibility; sequence; gene; cancer ... See more keywords
Colorectal cancer susceptibility loci and influence on survival
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1002/gcc.22674
Abstract: Genome‐wide association studies (GWAS) have identified multiple single‐nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. To evaluate the potential influence of colorectal cancer susceptibility SNPs on disease prognosis, we investigated whether GWAS‐identified colorectal cancer risk… read more here.
Keywords: cancer susceptibility; colorectal cancer; influence; cancer ... See more keywords
Association between the flap endonuclease 1 gene polymorphisms and cancer susceptibility: An updated meta‐analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28633
Abstract: Flap endonuclease 1 (FEN1) has emerged as an important enzyme in the maintenance of genomic instability and preventing carcinogenesis. The relationship between FEN1 −69G>A (rs174538)+4150G>T (rs4246215) polymorphisms and cancer susceptibility has been reported; however, results… read more here.
Keywords: flap endonuclease; cancer susceptibility; analysis; cancer ... See more keywords
Role of psychological background in cancer susceptibility genetic testing distress: It is not only about a positive result.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of genetic counseling"
DOI: 10.1002/jgc4.1687
Abstract: Clinical and familial factors predict psychological distress after genetic testing for cancer susceptibility. However, the contribution of an individual's psychological background to such distress is unclear. This study aims to analyze the psychological impact of… read more here.
Keywords: distress; cancer susceptibility; genetic testing; result ... See more keywords
Updates in Genetic Testing Guidelines for Breast Cancer Susceptibility Genes: a Change in the Paradigm
Sign Up to like & getrecommendations! Published in 2019 at "Current Breast Cancer Reports"
DOI: 10.1007/s12609-019-00339-x
Abstract: Up to 10% of all breast cancers are associated with inherited germline mutations. Genetic testing guidelines for hereditary breast cancer susceptibility have changed significantly since their inception in the late 1990s. The purpose of this… read more here.
Keywords: genetic testing; testing guidelines; breast; cancer susceptibility ... See more keywords
microRNAs in Cancer Susceptibility
Sign Up to like & getrecommendations! Published in 2017 at "Advances in Cancer Research"
DOI: 10.1016/bs.acr.2017.06.004
Abstract: &NA; microRNAs (miRNAs) are a small RNA species without protein‐coding potential. However, they are key modulators of protein translation. Many studies have linked miRNAs with cancer initiation, progression, diagnosis, and prognosis, and recent studies have… read more here.
Keywords: susceptibility; etiology; cancer susceptibility; micrornas cancer ... See more keywords
Association of CASP8 polymorphisms and cancer susceptibility: A meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173201
Abstract: Caspase-8 plays is an essential enzyme in apoptosis pathway. Several investigation have been done to identify the relation between CASP8 polymorphisms and different human cancers, but, the findings are still debated. The aim of the… read more here.
Keywords: risk; susceptibility; cancer susceptibility; polymorphisms ... See more keywords
Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2018.06.012
Abstract: Cellular oxidative stress plays a vital role in the pathological process of neural damage in cerebral ischemia/reperfusion (I/R). The breast cancer susceptibility protein 1 (BRCA1), a tumor suppressor, can modulate cellular antioxidant response and DNA… read more here.
Keywords: cancer susceptibility; cerebral ischemia; susceptibility protein; breast cancer ... See more keywords
Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
Sign Up to like & getrecommendations! Published in 2020 at "Translational Oncology"
DOI: 10.1016/j.tranon.2020.100774
Abstract: Based on epidemiological data provided by the World Health Organization (2018), cancer is the second most prevalent cause of death worldwide. Several factors are thought to contribute to the high mortality rate in cancer patients,… read more here.
Keywords: long noncoding; candidate casc9; cancer susceptibility; casc9 novel ... See more keywords
One step forward, two steps backward
Sign Up to like & getrecommendations! Published in 2019 at "Genetics in Medicine"
DOI: 10.1038/s41436-019-0660-5
Abstract: To the Editor: We wish to express our concerns about the policy statement of the American College of Medical Genetics and Genomics (ACMG) regarding secondary/incidental findings (SF) and population screening as it applies to cancer… read more here.
Keywords: cancer; susceptibility genes; population screening; cancer susceptibility ... See more keywords