Active mitochondrial respiration in cancer: a target for the drug.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04281-4
Abstract: The relative contribution of mitochondrial respiration and subsequent energy production in malignant cells has remained controversial to date. Enhanced aerobic glycolysis and impaired mitochondrial respiration have gained more attention in the metabolic study of cancer.… read more here.
Keywords: mitochondrial respiration; respiration cancer; respiration; active mitochondrial ... See more keywords
Insights into a Cancer-Target Demethylase: Substrate Prediction through Systematic Specificity Analysis for KDM3A
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050641
Abstract: Jumonji C (JmjC) lysine demethylases (KDMs) catalyze the removal of methyl (-CH3) groups from modified lysyl residues. Several JmjC KDMs promote cancerous properties and these findings have primarily been in relation to histone demethylation. However,… read more here.
Keywords: kdm3a; insights cancer; substrate; cancer target ... See more keywords
Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present
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DOI: 10.3390/biom12060815
Abstract: Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. As expression levels of human… read more here.
Keywords: cancer target; inhibitors cancer; ribonucleotide reductase; reductase ... See more keywords