Application of Liquid Biopsies in Cancer Targeted Therapy
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.764
Abstract: As a growing body of evidence demonstrates intertumoral and intratumoral heterogeneity and clonal evolution, both during carcinogenesis and also throughout treatment resulting in acquired drug resistance, the utility of blood‐based assays or “liquid biopsies” is… read more here.
Keywords: application liquid; liquid biopsies; biopsies cancer; targeted therapy ... See more keywords
Cancer-Targeted PEDF-DNA Therapy for Metastatic Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118999
Abstract: Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide. Moreover, metastasis is one of the main causes of death in CRC patients. Nanotechnology-based gene therapy has shown significant therapeutic benefits in recent clinical… read more here.
Keywords: therapy; colorectal cancer; pedf dna; cancer targeted ... See more keywords
Penile cancer: Targeted therapy in penile cancer: a new treatment paradigm
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/nrurol.2017.183
Abstract: Current advances in the understanding of penile carcinogenesis provide the possibility for new personalized and actionable targeted therapeutic approaches to improve outcomes in men with advanced penile cancer. Targeting the human epidermal growth factor receptor… read more here.
Keywords: cancer; targeted therapy; penile cancer; cancer targeted ... See more keywords
Tomographic magnetic particle imaging of cancer targeted nanoparticles.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c7nr05502a
Abstract: Magnetic Particle Imaging (MPI) is an emerging, whole body biomedical imaging technique, with sub-millimeter spatial resolution and high sensitivity to a biocompatible contrast agent consisting of an iron oxide nanoparticle core and a biofunctionalized shell.… read more here.
Keywords: imaging cancer; magnetic particle; particle imaging; cancer targeted ... See more keywords
A targeted siRNA‐loaded PDL1‐exosome and functional evaluation against lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14445
Abstract: As an endocytic nanosicle involved in intercellular communication, an exosome can efficiently deliver drugs from one cell to another and deliver therapeutic short interfering RNA (siRNA) to target cells. This is conducive to gene therapy… read more here.
Keywords: lung cancer; sirna loaded; targeted sirna; cancer targeted ... See more keywords
Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-16-0873
Abstract: Actin filaments, with their associated tropomyosin polymers, and microtubules are dynamic cytoskeletal systems regulating numerous cell functions. While antimicrotubule drugs are well-established, antiactin drugs have been more elusive. We previously targeted actin in cancer cells… read more here.
Keywords: antimicrotubule agents; identification cancer; cancer cells; cancer ... See more keywords
Abstract LB-B19: Re-sensitizing Pancreatic Cancer, targeted siRNA inhibition of HuR
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-lb-b19
Abstract: We have demonstrated that 3DNA nanocarriers can specifically, effectively, and safely deliver siRNA oligos targeted against a pro-survival hub, HuR (the ELAVL1 gene) in an in vivo, pre-clinical model of pancreatic cancer. Pancreatic cancer remains… read more here.
Keywords: targeted sirna; sensitizing pancreatic; hur; pancreatic cancer ... See more keywords
Bioresponsive cancer-targeted polysaccharide nanosystem to inhibit angiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s139405
Abstract: With many desirable features, such as being more effective and having multiple effects, antiangiogenesis has become one of the promising cancer treatments. The aim of this study was to design and synthesize a new targeted… read more here.
Keywords: targeted polysaccharide; bioresponsive cancer; polysaccharide nanosystem; mupr pop ... See more keywords
Cancer-Targeted Oncolytic Adenoviruses for Modulation of the Immune System.
Sign Up to like & getrecommendations! Published in 2018 at "Current cancer drug targets"
DOI: 10.2174/1568009617666170502152352
Abstract: Adenovirus is one of the most commonly used vectors for gene therapy and it is the first approved virus-derived drug for treatment of cancer. As an oncolytic agent, it can induce lysis of infected cells,… read more here.
Keywords: adenovirus; immune system; system; cancer targeted ... See more keywords
Ovarian Cancer Targeted Theranostics
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01537
Abstract: Ovarian cancer is a leading cause of death from gynecological malignancies. Although the prognosis is quite favorable if detected at an early stage, the vast majority of cases are diagnosed at an advanced stage, when… read more here.
Keywords: cancer; targeted theranostics; ovarian cancer; cancer targeted ... See more keywords