Systematic Screening and Therapeutic Evaluation of Glyconanoparticles with Differential Cancer Affinities for Targeted Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202203993
Abstract: Cancer‐targeting ligands used for nanomedicines have been limited mostly to antibodies, peptides, aptamers, and small molecules thus far. Here, a library of glycocalyx‐mimicking nanoparticles as a platform to enable screening and identification of cancer‐targeting nanomedicines… read more here.
Keywords: systematic screening; therapeutic evaluation; screening therapeutic; cancer targeting ... See more keywords
Traceable PEO-poly(ester) micelles for breast cancer targeting: The effect of core structure and targeting peptide on micellar tumor accumulation.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.08.001
Abstract: Traceable poly(ethylene oxide)-poly(ester) micelles were developed through chemical conjugation of a near-infrared (NIR) dye to the poly(ester) end by click chemistry. This strategy was tried for micelles with poly(ε-caprolactone) (PCL) or poly(α-benzyl carboxylate-ε-caprolactone) (PBCL) cores.… read more here.
Keywords: targeting peptide; cancer targeting; breast cancer; poly ester ... See more keywords
Hyaluronic acid conjugated multi-walled carbon nanotubes for colon cancer targeting.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.11.116
Abstract: Purpose of the present research was to evaluate in vitro and in vivo potential of gemcitabine (GEM) loaded hyaluronic acid (HA) conjugated PEGylated multi-walled carbon nanotubes (GEM/HA-PEG-MWCNTs) for effective colon cancer targeting. HA was conjugated… read more here.
Keywords: colon cancer; gem; cancer targeting; hyaluronic acid ... See more keywords
Optimization of cRGDfK ligand concentration on polymeric nanoparticles to maximize cancer targeting
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Industrial and Engineering Chemistry"
DOI: 10.1016/j.jiec.2019.09.006
Abstract: Abstract Optimization of ligand density on polymeric nanoparticles (PNPs) is critical for targeting solid tumors. Here, we prepared fluorescent cyanine 5.5 dye and cyclo(arginine–glycine–aspartic acid–phenylalanine–lysine) ligand-modified polyethylene glycol-poly(lactic-co-glycolic acid) (Cy 5.5-cRGDfK-PEG-PLGA) NPs with different ligand… read more here.
Keywords: polymeric nanoparticles; cancer targeting; crgdfk; concentration ... See more keywords
Targeting un-MET needs in advanced non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Lung cancer"
DOI: 10.1016/j.lungcan.2021.12.016
Abstract: Lung cancer classification has been radically transformed in recent years as genomic profiling has identified multiple novel therapeutic targets including MET exon 14 (METex14) alterations and MET amplification. Utilizing targeted therapies in patients with molecularly-defined… read more here.
Keywords: lung; cancer targeting; resistance; lung cancer ... See more keywords
ILC in chronic inflammation, cancer and targeting with biologicals.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2021.100963
Abstract: Since their discovery, Innate Lymphoid Cells (ILC) have emerged as important effector cells, serving multiple roles in maintaining tissue homeostasis and responding to tissue insults. As such, dysregulations of their function and distribution have been… read more here.
Keywords: chronic inflammation; cancer targeting; inflammation cancer; ilc chronic ... See more keywords
Engineered Cancer Targeting Microbes and Encapsulation Devices for Human Gut Microbiome Applications.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00251
Abstract: The gut microbiota produce specialized metabolites that are important for maintaining host health homeostasis. Hence, unstable production of these metabolites can contribute to diseases such as inflammatory bowel disease and colon cancer. While fecal transplantation… read more here.
Keywords: engineered cancer; microbes encapsulation; encapsulation devices; cancer targeting ... See more keywords
Intracellularly Activatable Nanovasodilators To Enhance Passive Cancer Targeting Regime.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b00495
Abstract: Conventional cancer targeting with nanoparticles has been based on the assumed enhanced permeability and retention (EPR) effect. The data obtained in clinical trials to date, however, have rarely supported the presence of such an effect.… read more here.
Keywords: nanovasodilators enhance; cancer targeting; activatable nanovasodilators; cancer ... See more keywords
Self-Reinforced Cancer Targeting (SRCT) Depending on Reciprocally Enhancing Feedback between Targeting and Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c10999
Abstract: Conventional cancer targeting methodology needs to be reformed to overcome the intrinsic barriers responsible for poor targeting efficiency. This study describes a concept of self-reinforced cancer targeting (SRCT) by correlating targeting with therapy in a… read more here.
Keywords: cancer; therapy; cancer targeting; self reinforced ... See more keywords
γδ T cells bring unconventional cancer-targeting to the clinic — again
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biotechnology"
DOI: 10.1038/s41587-020-0487-2
Abstract: A growing number of companies seek to unleash these unusual T cells against cancer. read more here.
Keywords: bring unconventional; cells bring; targeting clinic; cancer targeting ... See more keywords
Albumin as a "Trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials science"
DOI: 10.1039/c8bm00149a
Abstract: Although polymeric nanoconjugates (NCs) hold great promise for the treatment of cancer patients, their clinical utility has been hindered by the lack of efficient delivery of therapeutics to targeted tumor sites. Here, we describe an… read more here.
Keywords: albumin trojan; alb; trojan horse; cancer targeting ... See more keywords