Eph receptors as cancer targets for antibody-based therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2020.04.007
Abstract: Receptor tyrosine kinases (RTKs) are integral membrane sensors that govern cell differentiation, proliferation and mobility, and enable rapid communication between cells and their environment. Of the 20 RTK subfamilies currently known, Eph receptors are the… read more here.
Keywords: antibody based; eph receptors; receptors cancer; cancer targets ... See more keywords
Challenging cancer targets for aptamer delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2017.09.014
Abstract: The extraordinary boost in the understanding of the genetic and epigenetic mechanisms underlying the development and progression of different types of cancer, is offering an unprecedented hope for the development of precise therapeutics able to… read more here.
Keywords: targets aptamer; delivery; challenging cancer; cancer targets ... See more keywords
Exploring anti-liver cancer targets and mechanisms of oxyresveratrol: in silico and verified findings.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1985328
Abstract: The aim of current study was to exhume the potential targets and molecular mechanisms of oxyresveratrol, a structurally re-constructed resveratrol, for treating liver cancer through bioinformatics investigation and experimentative validation. To start with, the network… read more here.
Keywords: anti liver; mechanisms oxyresveratrol; cancer targets; cancer ... See more keywords
Identifying cancer targets based on machine learning methods via Chou's 5-steps rule and general pseudo components.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666191016155543
Abstract: In recent years, the successful implementation of human genome project has made people realize that genetic, environmental and lifestyle factors should be combined together to study cancer due to the complexity and various forms of… read more here.
Keywords: machine learning; identifying cancer; cancer targets; learning methods ... See more keywords
Integrated Analysis and Finding Reveal Anti–Liver Cancer Targets and Mechanisms of Pachyman (Poria cocos Polysaccharides)
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.742349
Abstract: This bioinformatics study aimed to characterize and certify crucial anti-cancer targets, functional processes, and molecular mechanisms of Pachyman in treating hepatocellular carcinoma (HCC) by using pharmacology network and molecular docking analyses, by experimental validation. The… read more here.
Keywords: hcc; pharmacology; cancer targets; vegfa ... See more keywords
TIM-3 Expression Is Downregulated on Human NK Cells in Response to Cancer Targets in Synergy with Activation
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12092417
Abstract: Among natural killer (NK) cell receptors, the T-cell immunoglobulin and mucin-containing domain (TIM-3) has been associated with both inhibitory and activating functions, depending on context and activation pathway. Ex vivo and in vitro, expression of… read more here.
Keywords: expression downregulated; expression; cancer targets; activation ... See more keywords