Combined RNA/tissue profiling identifies novel Cancer/Testis genes.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.12900
Abstract: Cancer/Testis (CT) genes are induced in germ cells, repressed in somatic cells and de-repressed in somatic tumors, where these genes can contribute to cancer progression. CT gene identification requires data obtained using standardized protocols and… read more here.
Keywords: testis; tissue; testis genes; cancer testis ... See more keywords
Targeted photodynamic therapy of cancer using a novel gallium (III) tris (ethoxycarbonyl) corrole conjugated‐mAb directed against cancer/testis antigens 83
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1601
Abstract: Photodynamic therapy (PDT) is a noninvasive, highly selective approach to the treatment of tumors. However, its therapeutic effect is limited by long‐lasting skin phototoxicity. Therefore, to compromise this shortcoming, it is preferable to deliver photosensitizers… read more here.
Keywords: ct83; photodynamic therapy; gallium iii; testis antigens ... See more keywords
Cancer‐testis gene STK31 is regulated by methylation and promotes the development of pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5472
Abstract: Pancreatic cancer (PC) is a highly invasive malignancy with extremely poor prognosis. STK31 has been identified as a cancer‐testis (CT) gene, but its function in PC has not been elucidated well. read more here.
Keywords: testis gene; pancreatic cancer; stk31; cancer ... See more keywords
Cancer testis antigen expression across T‐cell lymphoma subtypes
Sign Up to like & getrecommendations! Published in 2020 at "Hematological Oncology"
DOI: 10.1002/hon.2785
Abstract: To better understand the expression of cancer testis antigens (CTA) and its association with clinical outcomes on patients with T-cell lymphomas, we sought to establish a baseline level of expression of CTA across a diversity… read more here.
Keywords: cta; expression; testis antigen; cancer testis ... See more keywords
The expression of the cancer testis antigen MAGE A4: A favorable prognostic biomarker in salivary gland carcinomas related to low tumor grading
Sign Up to like & getrecommendations! Published in 2018 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.160
Abstract: Aim was to analyze the expression of different cancer testis antigens (CTA) and to assess its prognostic value in salivary gland carcinomas. read more here.
Keywords: gland carcinomas; salivary gland; expression; cancer testis ... See more keywords
A cancer/testis antigen, NY-SAR-35, induces EpCAM, CD44, and CD133, and activates ERK in HEK293 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.105
Abstract: The cancer/testis (CT) antigen NY-SAR-35 gene is located on the X chromosome and is aberrantly expressed in various cancers but not in normal tissues, other than testes. Previously, we reported the expression of NY-SAR-35 enhanced… read more here.
Keywords: hek293; hek293 cells; cancer testis; sar ... See more keywords
Cancer Testis Antigens in Sarcoma: Expression, Function and Immunotherapeutic Application.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.10.024
Abstract: Sarcomas are a group of heterogeneous malignancies of mesenchymal origin. Patient outcomes remain especially grim for those with recurrent or metastatic disease, and current therapeutic strategies have not significantly improved outcomes over the past few… read more here.
Keywords: testis; function; testis antigens; expression ... See more keywords
The role of Cancer/Testis Antigens in Multiple Myeloma pathogenesis and their application in disease monitoring and therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2018.09.010
Abstract: A unique group of genes, encoding tumour associated antigens, known as the Cancer/Testis Antigens (CTAs), have been explored as novel markers of disease progression and as targets of immunotherapy in several cancers, including the haematological… read more here.
Keywords: testis antigens; disease; pathogenesis; multiple myeloma ... See more keywords
Cancer/Testis Antigens into mitochondria: a hub between spermatogenesis, tumorigenesis and mitochondrial physiology adaptation.
Sign Up to like & getrecommendations! Published in 2020 at "Mitochondrion"
DOI: 10.1016/j.mito.2020.11.002
Abstract: Cancer/Testis Antigens (CTAs) genes are expressed only during spermatogenesis and tumorigenesis. Both processes share common specific metabolic adaptation related to energy supply, with a glucose to lactate gradient, leading to changes in mitochondrial physiology paralleling… read more here.
Keywords: spermatogenesis tumorigenesis; testis antigens; mitochondrial physiology; physiology ... See more keywords
Testicular miRNAs in relation to spermatogenesis, spermatogonial stem cells and cancer/testis genes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific African"
DOI: 10.1016/j.sciaf.2019.e00067
Abstract: Abstract The process of spermatogenesis in human involves three organized biological processes, through which spermatogonia cells undergo mitosis, meiosis and finally differentiation into mature spermatozoa. Spermatogenesis requires a specifically regulated gene expression patterns. The microRNAs… read more here.
Keywords: cancer; testis genes; stem; cancer testis ... See more keywords
Cancer-testis antigen expression is shared between epithelial ovarian cancer tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.03.512
Abstract: OBJECTIVES Cancer-testis (CT) antigens have been proposed as potential targets for cancer immunotherapy. Our objective was to evaluate the expression of a panel of CT antigens in epithelial ovarian cancer (EOC) tumor specimens, and to… read more here.
Keywords: epithelial ovarian; expression; antigen; ovarian cancer ... See more keywords