Antibody and antibody derivatives as cancer therapeutics.
Sign Up to like & getrecommendations! Published in 2019 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1556
Abstract: Antibodies are an important class of therapeutic for treating a wide range of diseases. These versatile macromolecules can be engineered to target many different antigens and to utilize several mechanisms of action to produce a… read more here.
Keywords: antibody antibody; derivatives cancer; antibody; drug ... See more keywords
The Evolving Landscape of Cancer Therapeutics.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2019_312
Abstract: The last 100 years have seen a dramatic alteration in the treatment of cancer. Aside from small molecule inhibitors of protein tyrosine kinases, monoclonal antibodies have also been found to provide valuable therapeutic approaches for modulating… read more here.
Keywords: landscape cancer; evolving landscape; biology; cancer ... See more keywords
Mitochondria and chronic effects of cancer therapeutics: The clinical implications
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02313-2
Abstract: One of the major mechanisms of action of chemo-radiation is to induce cellular senescence, which exerts crucial roles in age-related pathology. The concept of senescence is evolved, and the novel understanding of senescence-associated reprogramming/stemness has… read more here.
Keywords: chemo radiation; senescence; mitochondria chronic; cancer ... See more keywords
Nuclear Imaging for the Assessment of Cardiotoxicity from Chemotherapeutic Agents in Oncologic Disease
Sign Up to like & getrecommendations! Published in 2021 at "Current Cardiology Reports"
DOI: 10.1007/s11886-021-01493-4
Abstract: In this review, we summarize the major known cardiac toxicities of common chemotherapeutic agents and the role of nuclear cardiac imaging for the surveillance and assessment of cancer therapeutics–related cardiac dysfunction in routine clinical practice.… read more here.
Keywords: chemotherapeutic agents; therapeutics related; nuclear imaging; cardiotoxicity ... See more keywords
Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics
Sign Up to like & getrecommendations! Published in 2020 at "Science China Materials"
DOI: 10.1007/s40843-020-1387-7
Abstract: In recent years, the emerging two-dimensional (2D) nanomaterials have shown great potential for a variety of applications such as electronics, catalysis, supercapacitors, and energy materials. In the biomedical arena, these nanomaterials, especially 2D-ultrathin nanomaterials, have… read more here.
Keywords: recent advance; near infrared; ultrasound sensitive; infrared ultrasound ... See more keywords
Novel Sphingolipid‐Based Cancer Therapeutics in the Personalized Medicine Era: CHAPTER TWELVE
Sign Up to like & getrecommendations! Published in 2018 at "Advances in Cancer Research"
DOI: 10.1016/bs.acr.2018.04.016
Abstract: Abstract Sphingolipids are bioactive lipids that participate in a wide variety of biological mechanisms, including cell death and proliferation. The myriad of pro‐death and pro‐survival cellular pathways involving sphingolipids provide a plethora of opportunities for… read more here.
Keywords: medicine; sphingolipid based; sphingolipid metabolism; cancer ... See more keywords
Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.09.003
Abstract: Compounds that modulate H2O2 reaction networks have applications as targeted cancer therapeutics, as a subset of cancers exhibit sensitivity to this redox signal. Previous studies to identify therapeutics that induce oxidants have relied upon probes… read more here.
Keywords: peroxiredoxin; h2o2 mediated; screening compound; cancer therapeutics ... See more keywords
Lipid-polymer hybrid nanocarrier-mediated cancer therapeutics: current status and future directions.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.05.033
Abstract: The new generation of nanoparticles (NPs) encompass attributes of lipids and polymers and are referred to as 'lipid-polymer hybrid nanoparticles' (LPHNPs). LPHNPs have helped shed light on the mechanisms involved in targeted and non-specific drug… read more here.
Keywords: cancer therapeutics; hybrid nanocarrier; lipid polymer; polymer hybrid ... See more keywords
Bi-faceted delivery of phytochemicals through chitosan nanoparticles impregnated nanofibers for cancer therapeutics.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.09.093
Abstract: Drug delivery through nanotechnological approaches has predominantly gained significance owing to the enhanced bioavailability, stability and targeted sequel. Multiple drug delivery is also on its stride to achieve holistic therapeutic regime. In our quest for… read more here.
Keywords: delivery; faceted delivery; phytochemicals chitosan; delivery phytochemicals ... See more keywords
Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114771
Abstract: Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. Small molecules specifically inhibiting PIKfyve activity cause cytoplasmic vacuolation in all dividing cells in… read more here.
Keywords: pikfyve; pikfyve inhibitors; cancer cells; cancer ... See more keywords
Chemical Modulation of the Human Mitochondrial ClpP: Potential Application in Cancer Therapeutics.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00347
Abstract: The human ClpP proteolytic complex (HsClpP) is a serine protease located in the mitochondrial matrix and participates in the maintenance of the mitochondrial proteome among other cellular functions. HsClpP typically forms a multimeric complex with… read more here.
Keywords: hsclpp; modulation human; clpp; chemical modulation ... See more keywords