Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.0476
Abstract: Importance The clinical importance of genetic testing of BRCA1 and BRCA2 in breast, ovarian, prostate, and pancreatic cancers is widely recognized. However, there is insufficient evidence to include other cancer types that are potentially associated… read more here.
Keywords: pathogenic variants; brca1 brca2; cancer; cancer types ... See more keywords
Comprehensive profiling of pathogenic germline large genomic rearrangements in a pan-cancer analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13430
Abstract: The presence of large genomic rearrangements (LGRs) has been heavily investigated in breast and ovarian cancer. However, correlations between LGRs and cancer types beyond these two have not been extensively profiled, likely due to the… read more here.
Keywords: germline; pathogenic germline; lgrs; cancer types ... See more keywords
Analysis of the role of Frizzled 2 in different cancer types
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13111
Abstract: Frizzled 2 (FZD2) is an important receptor in the Wnt pathway, which is highly expressed in malignant tumors and helps regulate multiple tumor behaviors. Its expression level is related to prognosis. Here, bioinformatic analysis was… read more here.
Keywords: cancer types; analysis; gene expression; expression ... See more keywords
Identification of MET fusions in solid tumors: A multicenter, large scale study in China
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34361
Abstract: MET amplification and exon 14 skipping are well known as oncogenic drivers in multiple cancer types. However, MET fusions in most cancer types are poorly defined. To explore the profile and analyze the characteristics of… read more here.
Keywords: cancer; fusion; cancer types; met fusions ... See more keywords
A machine learning texture model for classifying lung cancer subtypes using preliminary bronchoscopic findings
Sign Up to like & getrecommendations! Published in 2018 at "Medical Physics"
DOI: 10.1002/mp.13241
Abstract: PURPOSE Bronchoscopy is useful in lung cancer detection, but cannot be used to differentiate cancer types. A computer-aided diagnosis (CAD) system was proposed to distinguish malignant cancer types to achieve objective diagnoses. METHODS Bronchoscopic images… read more here.
Keywords: cancer types; machine learning; bronchoscopic; lung cancer ... See more keywords
Bayesian methods for the analysis of early-phase oncology basket trials with information borrowing across cancer types.
Sign Up to like & getrecommendations! Published in 2020 at "Statistics in medicine"
DOI: 10.1002/sim.8675
Abstract: Research in oncology has changed the focus from histological properties of tumors in a specific organ to a specific genomic aberration potentially shared by multiple cancer types. This motivates the basket trial, which assesses the… read more here.
Keywords: cancer; cancer types; oncology; information borrowing ... See more keywords
Pathways‐ and epigenetic‐based assessment of relative immune infiltration in various types of solid tumors
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Cancer Research"
DOI: 10.1016/bs.acr.2019.01.003
Abstract: &NA; Recent clinical studies document the power of immunotherapy in treating subsets of patients with advanced cancers. In this context and with multiple cancer immunotherapeutics already evaluated in the clinic and a large number in… read more here.
Keywords: cancer; pathways epigenetic; cancer types; immune infiltration ... See more keywords
Comment on "A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets," Cancer Lett. 2016 Nov 28; 382 (2): 203-214.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.02.002
Abstract: I read with interest the recent Cancer Letters article by Jia et al. [1]. I would like to point out that the computational discovery of the multi-cancer nature of the signature has already been previously… read more here.
Keywords: cancer types; col11a1; signature; cancer ... See more keywords
Class Imbalance in Out-of-Distribution Datasets: Improving the Robustness of the TextCNN for the Classification of Rare Cancer Types.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomedical informatics"
DOI: 10.1016/j.jbi.2021.103957
Abstract: In the last decade, the widespread adoption of electronic health record documentation has created huge opportunities for information mining. Natural language processing (NLP) techniques using machine and deep learning are becoming increasingly widespread for information… read more here.
Keywords: cancer types; pathology; class imbalance; cancer ... See more keywords
Bokhman Redux: Endometrial cancer "types" in the 21st century.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2016.12.010
Abstract: In 1983 Jan V. Bokhman, M.D. published a landmark paper entitled "Two Pathogenetic Types of Endometrial Carcinoma" in which an enduring dualistic view of endometrial cancer was first proposed. "Type I" cancers are thought to… read more here.
Keywords: cancer types; endometrial cancer; redux endometrial; cancer ... See more keywords
Role of stem-cell divisions in cancer risk
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature23302
Abstract: We recently reported a strong correlation between the incidence of cancers and the number of stem-cell divisions in the corresponding normal tissues1. We interpreted this correlation to mean that random genomic alterations (termed replicative or… read more here.
Keywords: cancer types; risk; line; extrinsic risk ... See more keywords