CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.076
Abstract: Cyclin-dependent kinases 8 (CDK8) regulates transcriptional process via associating with the mediator complex or phosphorylating transcription factors (TF). Overexpression of CDK8 has been observed in various cancers. It mediates aberrant activation of Wnt/β-catenin signaling pathway,… read more here.
Keywords: cdk8 inhibitors; cdk8 therapeutic; cdk8; cancers recent ... See more keywords
Modulation of reactive oxygen species in cancers: recent advances
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2022.2133704
Abstract: Abstract Oxidation-reduction reactions played a significant role in the chemical evolution of life forms on oxygenated earth. Cellular respiration is dependent on such redox reactions, and any imbalance leads to the accumulation of reactive oxygen… read more here.
Keywords: cancers recent; reactive oxygen; modulation reactive; oxygen species ... See more keywords