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Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-09989-9
Abstract: Randomized studies have reported a positive effect of candesartan, an angiotensin II receptor antagonist, in migraine prevention. The aim of our study was to explore patient subjective efficacy of candesartan in a real-world sample of…
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Keywords:
migraine;
candesartan;
real world;
study ... See more keywords
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Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02310
Abstract: A novel 7-((4-(3-((2-[18F]fluoropyridin-3-yl)oxy)propyl)-1H-1,2,3-triazol-1-yl)methyl)-1H-benzo[d]imidazole derivative of the angiotensin II type-1 receptor (AT1R) blocker candesartan, [18F]fluoropyridine–candesartan, was synthesized via the copper-catalyzed azide–alkyne cycloaddition click reaction between 2-[18F]fluoro-3-(pent-4-yn-1-yloxy)pyridine ([18F]FPyKYNE) and the tetrazole-protected azido-candesartan derivative, followed by acid deprotection.…
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Keywords:
candesartan;
fluoropyridine candesartan;
chemistry;
18f fluoropyridine ... See more keywords
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Published in 2020 at "Drug Delivery"
DOI: 10.1080/10717544.2020.1760961
Abstract: Abstract During the last decades, much attention has been focused on SNEDDS approach to resolve concerns of BCS II class drugs with accentuation on upgrading the solubility and bioavailability. The present hypothesis confirms the theory…
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Keywords:
candesartan;
candesartan loaded;
delivery;
drug ... See more keywords
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Published in 2022 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsac018
Abstract: BACKGROUND Two fixed-dose combination tablets of amlodipine with bisoprolol and amlodipine with candesartan were recently approved for the treatment of hypertension. OBJECTIVE Three UV spectrophotometric analytical methods were developed for the estimation of the above…
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Keywords:
candesartan;
method;
bisoprolol;
amlodipine ... See more keywords
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Published in 2021 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000126
Abstract: Growing evidence suggests that certain glucuronides function as potent inhibitors of CYP2C8. We previously reported the possibility of drug-drug interactions between candesartan cilexetil and paclitaxel. In this study, we evaluated the effects of candesartan N2-glucuronide…
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Keywords:
candesartan acyl;
candesartan;
acyl glucuronide;
drug ... See more keywords
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Published in 2023 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2023/5107317
Abstract: Simple, accurate, precise, and cost-effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H-point standard addition, Q-absorption ratio, and correction absorbance spectrophotometric techniques were utilized for…
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Keywords:
candesartan cilexetil;
candesartan;
simultaneous determination;
cilexetil hydrochlorothiazide ... See more keywords
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Published in 2017 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-017-0879-x
Abstract: The aim of the present work is to answer the question is it possible to replace the ester prodrug candesartan cilexetil (CC) by its active metabolite candesartan (C) to bypass the in vivo variable effect…
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Keywords:
candesartan cilexetil;
candesartan;
vivo;
vivo studies ... See more keywords
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Published in 2017 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20176665
Abstract: Minimal hepatic encephalopathy is more common than the acute syndrome. Losartan, the first angiotensin-II receptor blocker (ARB), and candesartan, another widely-used ARB, have protected against developing fibrogenesis, but there is no clear data about their…
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Keywords:
chronic liver;
liver failure;
candesartan;
motor dysfunction ... See more keywords
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Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.870627
Abstract: Aberrant activation of the NLRP3 inflammasome promotes the pathogenesis of many inflammatory diseases. The development of the NLRP3 inflammasome inhibitors from existing drugs for new therapeutic purposes is becoming more important. Candesartan is an angiotensin…
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Keywords:
receptor antagonist;
candesartan;
anti inflammatory;
angiotensin receptor ... See more keywords
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Published in 2020 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics12020086
Abstract: The aim of this work was to assess the impact of an excipient in a pharmaceutical formulation containing candesartan cilexetil over the decomposition of the active pharmaceutical ingredient and to comparatively investigate the kinetics of…
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Keywords:
degradation;
candesartan cilexetil;
candesartan;
pure ... See more keywords
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Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13040497
Abstract: Candesartan cilexetil (CC), a prodrug and highly effective antihypertensive agent, is a poorly soluble (BCS Class II) drug with limited bioavailability. Here, we attempted to improve CC’s bioavailability by formulating several CC-loaded amorphous solid dispersions…
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Keywords:
candesartan cilexetil;
candesartan;
solid dispersion;
drug ... See more keywords