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   Articles with "candesartan cilexetil" as a keyword



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Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

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recommendations! Published in 2023 at "Journal of Analytical Methods in Chemistry"

DOI: 10.1155/2023/5107317

Abstract: Simple, accurate, precise, and cost-effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H-point standard addition, Q-absorption ratio, and correction absorbance spectrophotometric techniques were utilized for… read more here.

Keywords: candesartan cilexetil; candesartan; simultaneous determination; cilexetil hydrochlorothiazide ... See more keywords
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Comparative Pharmaceutical Evaluation of Candesartan and Candesartan Cilexetil: Physicochemical Properties, In Vitro Dissolution and Ex Vivo In Vivo Studies

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recommendations! Published in 2017 at "AAPS PharmSciTech"

DOI: 10.1208/s12249-017-0879-x

Abstract: The aim of the present work is to answer the question is it possible to replace the ester prodrug candesartan cilexetil (CC) by its active metabolite candesartan (C) to bypass the in vivo variable effect… read more here.

Keywords: candesartan cilexetil; candesartan; vivo; vivo studies ... See more keywords
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Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug

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recommendations! Published in 2020 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s248511

Abstract: Purpose The objective of this study was to compare different techniques to enhance the solubility and dissolution rate, and hence the bioavailability of candesartan cilexetil. Methods To achieve this target, various techniques were employed such… read more here.

Keywords: bioavailability; dissolution rate; bioavailability candesartan; drug ... See more keywords
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Nephroprotective effects of Candesartan Cilexetil against Cyclosporine A-induced nephrotoxicity in a rat model

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recommendations! Published in 2022 at "Journal of Medicine and Life"

DOI: 10.25122/jml-2021-0227

Abstract: Cyclosporine A (CsA), a well-known immunosuppressive drug, has been prescribed after organ transplantation and in a variety of disorders with an immunological origin. Nephrotoxicity is one of the most frequently stated problems associated with CsA,… read more here.

Keywords: treated group; candesartan cilexetil; group; csa ... See more keywords
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Solid State Stability and Kinetics of Degradation for Candesartan—Pure Compound and Pharmaceutical Formulation

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recommendations! Published in 2020 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics12020086

Abstract: The aim of this work was to assess the impact of an excipient in a pharmaceutical formulation containing candesartan cilexetil over the decomposition of the active pharmaceutical ingredient and to comparatively investigate the kinetics of… read more here.

Keywords: degradation; candesartan cilexetil; candesartan; pure ... See more keywords
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Developing pH-Modulated Spray Dried Amorphous Solid Dispersion of Candesartan Cilexetil with Enhanced In Vitro and In Vivo Performance

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recommendations! Published in 2021 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics13040497

Abstract: Candesartan cilexetil (CC), a prodrug and highly effective antihypertensive agent, is a poorly soluble (BCS Class II) drug with limited bioavailability. Here, we attempted to improve CC’s bioavailability by formulating several CC-loaded amorphous solid dispersions… read more here.

Keywords: candesartan cilexetil; candesartan; solid dispersion; drug ... See more keywords
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Candesartan cilexetil loaded nanodelivery systems for improved oral bioavailability.

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recommendations! Published in 2017 at "Therapeutic delivery"

DOI: 10.4155/tde-2016-0063

Abstract: Candesartan cilexetil (CC), an antihypertensive drug, has low oral bioavailability due to poor solubility and hepatic first-pass metabolism. These are major limitations in oral delivery of CC. Several approaches are known to reduce the problems… read more here.

Keywords: candesartan cilexetil; oral bioavailability; improved oral; delivery ... See more keywords
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Concomitant administration of candesartan cilexetil in patients on paclitaxel and carboplatin combination therapy increases risk of severe neutropenia
.

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recommendations! Published in 2018 at "International journal of clinical pharmacology and therapeutics"

DOI: 10.5414/cp203180

Abstract: OBJECTIVE Angiotensin receptor blockers (ARBs) are often used in patients on paclitaxel (PTX) and carboplatin combination (TC) therapy to treat hypertension caused by the co-administration of bevacizumab. The aim of this retrospective study was to… read more here.

Keywords: therapy; combination therapy; candesartan cilexetil; severe neutropenia ... See more keywords
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Pharmacokinetics of a new fixed-dose combination of candesartan cilexetil, hydrochlorothiazide and rosuvastatin in healthy adult subjects.

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recommendations! Published in 2022 at "International journal of clinical pharmacology and therapeutics"

DOI: 10.5414/cp204026

Abstract: BACKGROUND A fixed-dose combination (FDC) of candesartan cilexetil, hydrochlorothiazide and rosuvastatin (CC/HCTZ/RSV) has been developed to enhance patient compliance in the primary prevention of cardiovascular diseases. OBJECTIVE To evaluate if the combination of the product… read more here.

Keywords: dissolution; fixed dose; combination; candesartan cilexetil ... See more keywords

Formulation and Evaluation of directly compressed Floating Tablets of Candesartan Cilexetil for Gastro Retentive Drug Delivery

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recommendations! Published in 2018 at "Research Journal of Pharmacy and Technology"

DOI: 10.5958/0974-360x.2018.00517.6

Abstract: The candesartan cilexetil floating matrix drug delivery system was design to prolong the gastric residence time and improve its bioavailability. The candesartan cilexetil floating matrix tablet was prepared by using direct compression technique. Various natural… read more here.

Keywords: evaluation directly; candesartan cilexetil; drug delivery; drug ... See more keywords
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Formulation and In-vitro Characterization of Self Nano-emulsifying Drug Delivery System (SNEDDS) for enhanced Solubility of Candesartan Cilexetil

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recommendations! Published in 2019 at "Research Journal of Pharmacy and Technology"

DOI: 10.5958/0974-360x.2019.00440.2

Abstract: Candesartan cilexetil is the prodrug of candesartan, a selective angiotensin II receptor antagonist, used in the management of hypertension and heart failure. It is characterized by poor aqueous solubility resulting in low bioavailability. Self-nanoemulsifying drug… read more here.

Keywords: formulation; drug; candesartan cilexetil; delivery ... See more keywords