Pharmacokinetic Comparison of a Fixed-Dose Combination of Candesartan Cilexetil/Amlodipine/Atorvastatin Versus Co-administration of Individual Formulations in Healthy Participants
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DOI: 10.1007/s12325-024-02869-y
Abstract: Fixed-dose combinations (FDCs) of angiotensin II receptor blockers, calcium channel blockers, and statins are conventional therapeutic interventions prescribed for cardiovascular diseases. This study aimed at drawing a comparison between the pharmacokinetics and safety of an… read more here.
Keywords: candesartan cilexetil; cilexetil amlodipine; individual formulations; amlodipine atorvastatin ... See more keywords
Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations
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DOI: 10.1155/2023/5107317
Abstract: Simple, accurate, precise, and cost-effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H-point standard addition, Q-absorption ratio, and correction absorbance spectrophotometric techniques were utilized for… read more here.
Keywords: candesartan cilexetil; candesartan; simultaneous determination; cilexetil hydrochlorothiazide ... See more keywords
Comparative Pharmaceutical Evaluation of Candesartan and Candesartan Cilexetil: Physicochemical Properties, In Vitro Dissolution and Ex Vivo In Vivo Studies
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DOI: 10.1208/s12249-017-0879-x
Abstract: The aim of the present work is to answer the question is it possible to replace the ester prodrug candesartan cilexetil (CC) by its active metabolite candesartan (C) to bypass the in vivo variable effect… read more here.
Keywords: candesartan cilexetil; candesartan; vivo; vivo studies ... See more keywords
Solid dispersion systems for enhanced dissolution of poorly water-soluble candesartan cilexetil: In vitro evaluation and simulated pharmacokinetics studies
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DOI: 10.1371/journal.pone.0303900
Abstract: Background Candesartan cilexetil (CC) is a selective angiotensin II receptor antagonist widely used to treat hypertension. CC is a substrate of P-glycoprotein (P-gp), causing its efflux to the intestinal lumen. It is also practically insoluble… read more here.
Keywords: candesartan cilexetil; water; dissolution; solid dispersion ... See more keywords
Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug
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DOI: 10.2147/dddt.s248511
Abstract: Purpose The objective of this study was to compare different techniques to enhance the solubility and dissolution rate, and hence the bioavailability of candesartan cilexetil. Methods To achieve this target, various techniques were employed such… read more here.
Keywords: bioavailability; dissolution rate; bioavailability candesartan; drug ... See more keywords
Nephroprotective effects of Candesartan Cilexetil against Cyclosporine A-induced nephrotoxicity in a rat model
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DOI: 10.25122/jml-2021-0227
Abstract: Cyclosporine A (CsA), a well-known immunosuppressive drug, has been prescribed after organ transplantation and in a variety of disorders with an immunological origin. Nephrotoxicity is one of the most frequently stated problems associated with CsA,… read more here.
Keywords: treated group; candesartan cilexetil; group; csa ... See more keywords
Solid State Stability and Kinetics of Degradation for Candesartan—Pure Compound and Pharmaceutical Formulation
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DOI: 10.3390/pharmaceutics12020086
Abstract: The aim of this work was to assess the impact of an excipient in a pharmaceutical formulation containing candesartan cilexetil over the decomposition of the active pharmaceutical ingredient and to comparatively investigate the kinetics of… read more here.
Keywords: degradation; candesartan cilexetil; candesartan; pure ... See more keywords
Developing pH-Modulated Spray Dried Amorphous Solid Dispersion of Candesartan Cilexetil with Enhanced In Vitro and In Vivo Performance
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DOI: 10.3390/pharmaceutics13040497
Abstract: Candesartan cilexetil (CC), a prodrug and highly effective antihypertensive agent, is a poorly soluble (BCS Class II) drug with limited bioavailability. Here, we attempted to improve CC’s bioavailability by formulating several CC-loaded amorphous solid dispersions… read more here.
Keywords: candesartan cilexetil; candesartan; solid dispersion; drug ... See more keywords
Candesartan cilexetil loaded nanodelivery systems for improved oral bioavailability.
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DOI: 10.4155/tde-2016-0063
Abstract: Candesartan cilexetil (CC), an antihypertensive drug, has low oral bioavailability due to poor solubility and hepatic first-pass metabolism. These are major limitations in oral delivery of CC. Several approaches are known to reduce the problems… read more here.
Keywords: candesartan cilexetil; oral bioavailability; improved oral; delivery ... See more keywords
Concomitant administration of candesartan cilexetil in patients on paclitaxel and carboplatin combination therapy increases risk of severe neutropenia .
Sign Up to like & getrecommendations! Published in 2018 at "International journal of clinical pharmacology and therapeutics"
DOI: 10.5414/cp203180
Abstract: OBJECTIVE Angiotensin receptor blockers (ARBs) are often used in patients on paclitaxel (PTX) and carboplatin combination (TC) therapy to treat hypertension caused by the co-administration of bevacizumab. The aim of this retrospective study was to… read more here.
Keywords: therapy; combination therapy; candesartan cilexetil; severe neutropenia ... See more keywords
Pharmacokinetics of a new fixed-dose combination of candesartan cilexetil, hydrochlorothiazide and rosuvastatin in healthy adult subjects.
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DOI: 10.5414/cp204026
Abstract: BACKGROUND A fixed-dose combination (FDC) of candesartan cilexetil, hydrochlorothiazide and rosuvastatin (CC/HCTZ/RSV) has been developed to enhance patient compliance in the primary prevention of cardiovascular diseases. OBJECTIVE To evaluate if the combination of the product… read more here.
Keywords: dissolution; fixed dose; combination; candesartan cilexetil ... See more keywords