Transposon-based screen identifies a XRE family regulator crucial for candicidin biosynthesis in Streptomyces albus J1074
Sign Up to like & getrecommendations! Published in 2020 at "Science China Life Sciences"
DOI: 10.1007/s11427-019-1582-5
Abstract: Polyene macrolides are a group of natural products with potent antifungal activity (Caffrey et al., 2016). Candicidin/ FR-008, a potent broad-spectrum anti-fungal agent, is produced by several Streptomycetes, including Streptomycetes sp. strain FR-008 (Chen et… read more here.
Keywords: production; candicidin biosynthesis; candicidin; family ... See more keywords
Light-Induced Transformation of the Aromatic Heptaene Antifungal Antibiotic Candicidin D into Its All-Trans Isomer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.7b00821
Abstract: Illumination of the aromatic heptaene macrolide antifungal antibiotic candicicin D with UV light results in an isomerization of the molecule. The product formed after irradiation of the candicidin complex with UV light (λ = 365… read more here.
Keywords: antifungal antibiotic; aromatic heptaene; light induced; candicidin ... See more keywords