Multiple interfaces control activity of the Candida glabrata Pdr1 transcription factor mediating azole drug resistance
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DOI: 10.1007/s00294-018-0870-4
Abstract: The Cys6Zn2 DNA-binding domain transcription factor Pdr1 is a central regulator of drug resistance in the pathogenic yeast Candida glabrata. In this review, I discuss the multiple control mechanisms modulating the function of this positive… read more here.
Keywords: drug resistance; transcription factor; candida glabrata;
Activity of Combined Antifungal Agents Against Multidrug-Resistant Candida glabrata Strains
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DOI: 10.1007/s11046-017-0141-9
Abstract: In this study, we evaluated the in vitro activity of echinocandins, azoles, and amphotericin B alone and in combination against echinocandin/azole-sensitive and echinocandin/azole-resistant Candida glabrata isolates. Susceptibility tests were performed using the broth microdilution method… read more here.
Keywords: glabrata strains; glabrata; multidrug resistant; resistant candida ... See more keywords
New antifungal ent-labdane diterpenes against Candida glabrata produced by microbial transformation of ent-polyalthic acid.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103560
Abstract: Candida glabrata, the most common non-albicans Candida species and one of the primary causes of candidemia, exhibits decreased susceptibility to azoles and more recently to echinocandins. Polyalthic acid 1, a furan diterpene, has been shown… read more here.
Keywords: glabrata produced; ent; produced microbial; polyalthic acid ... See more keywords
Impact of high MIC of fluconazole on outcomes of Candida glabrata bloodstream infection: a retrospective multicenter cohort study.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.05.001
Abstract: To evaluate the impacts of fluconazole minimum inhibitory concentration (MIC) according to primary antifungal agents on Candida glabrata bloodstream infection (BSI), a multicenter retrospective cohort study was conducted in Korea, concerning the time period from… read more here.
Keywords: candida glabrata; bloodstream infection; glabrata bloodstream; study ... See more keywords
Brain abscess due to Candida glabrata in an immunocompetent patient. A case report with update and literature review
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DOI: 10.1016/j.idcr.2020.e00996
Abstract: Candida spp. brain abscess is scare. Clinical presentation is unspecific. Diagnosis requires mycological culture of a puncture or biopsy specimen. Therapeutic management is based on prolonged course of azole or liposomal amphotericin B. We reported… read more here.
Keywords: candida; brain abscess; candida glabrata; case ... See more keywords
Evaluation of four calcium channel blockers as fluconazole resistance inhibitors in Candida glabrata.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2018.04.004
Abstract: OBJECTIVES The aim of this study was to evaluate the ability of four calcium channel blockers (CCBs), namely verapamil, diltiazem, nicardipine (NIC) and nifedipine (NIF), to enhance the susceptibility of Candida glabrata strains to fluconazole… read more here.
Keywords: candida glabrata; calcium channel; four calcium; effect ... See more keywords
Candida glabrata is a successful pathogen: An artist manipulating the immune response.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiological research"
DOI: 10.1016/j.micres.2022.127038
Abstract: In recent years, Candida glabrata has emerged as a clinically important pathogen causing invasive infections and death. This review highlights the main virulence factors of this fungus and its strategies to subvert the cell response… read more here.
Keywords: pathogen; response; pathogen artist; glabrata successful ... See more keywords
Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis
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DOI: 10.1016/j.mmcr.2021.03.003
Abstract: Candida infections of the central nervous system (CNS) are rare. We report a case of Candida glabrata meningitis successfully treated with combination antifungal therapy followed by step-down therapy with fluconazole. New-onset hypercalcaemia, an uncommon side… read more here.
Keywords: treatment; case; treatment cessation; glabrata meningitis ... See more keywords
Transcriptional responses of Candida glabrata biofilm cells to fluconazole are modulated by the carbon source.
Sign Up to like & getrecommendations! Published in 2020 at "NPJ biofilms and microbiomes"
DOI: 10.1038/s41522-020-0114-5
Abstract: Candida glabrata is an important human fungal pathogen known to trigger serious infections in immune-compromised individuals. Its ability to form biofilms, which exhibit high tolerance to antifungal treatments, has been considered as an important virulence… read more here.
Keywords: glabrata biofilm; carbon; glabrata; carbon source ... See more keywords
Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata
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DOI: 10.1038/s41598-019-39117-1
Abstract: The human fungal pathogen Candida glabrata appears to utilise unique stealth, evasion and persistence strategies in subverting the onslaught of host immune response during systemic infection. However, macrophages actively deprive the intracellular fungal pathogen of… read more here.
Keywords: virulence; glyoxylate cycle; glabrata; candida glabrata ... See more keywords
Trk1-mediated potassium uptake contributes to cell-surface properties and virulence of Candida glabrata
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DOI: 10.1038/s41598-019-43912-1
Abstract: The absence of high-affinity potassium uptake in Candida glabrata, the consequence of the deletion of the TRK1 gene encoding the sole potassium-specific transporter, has a pleiotropic effect. Here, we show that in addition to changes… read more here.
Keywords: potassium uptake; glabrata; surface properties; cell surface ... See more keywords