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   Articles with "candidalysin" as a keyword



Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09915-2

Abstract: Candida albicans is a fungal pathobiont, able to cause epithelial cell damage and immune activation. These functions have been attributed to its secreted toxin, candidalysin, though the molecular mechanisms are poorly understood. Here, we identify… read more here.

Keywords: immune responses; factor receptor; growth factor; candidalysin ... See more keywords

Global fungal-host interactome mapping identifies host targets of candidalysin

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-46141-x

Abstract: Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we performed a high-throughput enhanced yeast two-hybrid… read more here.

Keywords: candidalysin; dna damage; host targets; targets candidalysin ... See more keywords

The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways

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recommendations! Published in 2022 at "Science signaling"

DOI: 10.1126/scisignal.abj6915

Abstract: The fungal pathogen Candida albicans secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MAPK) pathways and… read more here.

Keywords: candidalysin; toxin candidalysin; erk; mapk ... See more keywords

Variations in candidalysin amino acid sequence influence toxicity and host responses

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recommendations! Published in 2024 at "mBio"

DOI: 10.1128/mbio.03351-23

Abstract: ABSTRACT Candida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of… read more here.

Keywords: candidalysin; candidalysin variants; ability; amino acid ... See more keywords

Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins

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recommendations! Published in 2022 at "mBio"

DOI: 10.1128/mbio.03510-21

Abstract: Pathogenic fungi kill an estimated 1.5 million people every year. Recently, we discovered that the fungal pathogen Candida albicans secretes a peptide toxin called candidalysin during mucosal infection. ABSTRACT Candidalysin is the first cytolytic peptide… read more here.

Keywords: peptide; peptide toxins; dubliniensis tropicalis; pathogenic fungi ... See more keywords