Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
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DOI: 10.1021/acs.jmedchem.4c00580
Abstract: Herein, we describe the design and synthesis of γ-secretase modulator (GSM) clinical candidate PF-06648671 (22) for the treatment of Alzheimer's disease. A key component of the design involved a 2,5-cis-tetrahydrofuran (THF) linker to impart conformational… read more here.
Keywords: alzheimer disease; treatment alzheimer; secretase modulator; candidate 06648671 ... See more keywords