Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
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DOI: 10.1021/acs.jmedchem.2c01342
Abstract: Due to increased reliance on glycolysis, which produces lactate, monocarboxylate transporters (MCTs) are often upregulated in cancer. MCT4 is associated with the export of lactic acid from cancer cells under hypoxia, so inhibition of MCT4… read more here.
Keywords: oncology; monocarboxylate; clinical candidate; candidate azd0095 ... See more keywords