Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits.
Sign Up to like & getrecommendations! Published in 2022 at "Nature genetics"
DOI: 10.1038/s41588-021-00987-9
Abstract: While large-scale, genome-wide association studies (GWAS) have identified hundreds of loci associated with brain-related traits, identification of the variants, genes and molecular mechanisms underlying these traits remains challenging. Integration of GWAS with expression quantitative trait… read more here.
Keywords: analysis; causal variants; brain related; related traits ... See more keywords
Combining GWAS and TWAS to identify candidate causal genes for tocochromanol levels in maize grain
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac091
Abstract: Tocochromanols (tocopherols and tocotrienols, collectively vitamin E) are lipid-soluble antioxidants important for both plant fitness and human health. The main dietary sources of vitamin E are seed oils that often accumulate high levels of tocopherol… read more here.
Keywords: candidate causal; tocochromanol levels; maize grain; seed ... See more keywords
Prioritized candidate causal haplotype blocks in plant genome-wide association studies
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010437
Abstract: Genome wide association studies (GWAS) can play an essential role in understanding genetic basis of complex traits in plants and animals. Conventional SNP-based linear mixed models (LMM) that marginally test single nucleotide polymorphisms (SNPs) have… read more here.
Keywords: haplotype blocks; candidate causal; genome wide; gwas ... See more keywords