Screening approach for identifying candidate drugs and drug‐drug interactions related to hip fracture risk in persons with Alzheimer disease
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4232
Abstract: To assess whether a “drugome‐wide” screen with case‐crossover design is a feasible approach for identifying candidate drugs and drug‐drug interactions. read more here.
Keywords: candidate drugs; approach identifying; identifying candidate; drug ... See more keywords
Identification of new candidate drugs for primary Sjögren's syndrome using a drug repurposing transcriptomic approach.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1136/annrheumdis-2022-eular.1998
Abstract: OBJECTIVES To date, no immunomodulatory drug has demonstrated its efficacy in primary Sjögren's syndrome (pSS). We sought to analyze potential commonalities between pSS transcriptomic signatures and signatures of various drugs or specific knock-in or knock-down… read more here.
Keywords: primary gren; knock; gren syndrome; knock genes ... See more keywords
Building the drug-GO function network to screen significant candidate drugs for myasthenia gravis
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0214857
Abstract: Myasthenia gravis (MG) is an autoimmune disease. In recent years, considerable evidence has indicated that Gene Ontology (GO) functions, especially GO-biological processes, have important effects on the mechanisms and treatments of different diseases. However, the… read more here.
Keywords: candidate drugs; drug function; function network;
Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase
Sign Up to like & getrecommendations! Published in 2021 at "Oncotarget"
DOI: 10.18632/oncotarget.28021
Abstract: Introduction: Treatment options for biliary tract cancer (BTC) are very limited. It is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase (KB) and characterize BTCs immunologically for evaluating the actionability of… read more here.
Keywords: actionability; actionable genes; biliary tract; candidate drugs ... See more keywords
Identification of Prognostic Signature and Gliclazide as Candidate Drugs in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.665276
Abstract: Background Lung adenocarcinoma (LUAD) is the most common pathological type of lung cancer, with high incidence and mortality. To improve the curative effect and prolong the survival of patients, it is necessary to find new… read more here.
Keywords: lung adenocarcinoma; candidate drugs; luad; signature ... See more keywords
Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14050458
Abstract: Alzheimer’s disease (AD; progressive neurodegenerative disorder) is associated with cognitive and functional impairment with accompanying neuropsychiatric symptoms. The available pharmacological treatment is of a symptomatic nature and, as such, it does not modify the cause… read more here.
Keywords: candidate drugs; pharmacotherapy alzheimer; alzheimer disease; disease ... See more keywords