In Vitro Evaluation of Candidate Gene Targets for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9220-1_2
Abstract: Discovery and development of gene targets for cancer therapeutics are lengthy and highly costly processes. Identification and evaluation of candidate gene targets are of fundamental importance. RNA interference allows candidate genes to be specifically and… read more here.
Keywords: gene targets; targets cancer; candidate gene; cancer ... See more keywords
Genetic mapping and development of co-segregating markers of RpsQ, which provides resistance to Phytophthora sojae in soybean
Sign Up to like & getrecommendations! Published in 2017 at "Theoretical and Applied Genetics"
DOI: 10.1007/s00122-017-2883-7
Abstract: Key messageThe RpsQ Phytophthora resistance locus was finely mapped to a 118-kb region on soybean chromosome 3. A best candidate gene was predicted and three co-segregating gene markers were developed.AbstractPhytophthora root rot (PRR), caused by… read more here.
Keywords: rpsq; resistance; candidate gene; gene ... See more keywords
Genetic mapping reveals a candidate gene for egusi seed in watermelon
Sign Up to like & getrecommendations! Published in 2019 at "Euphytica"
DOI: 10.1007/s10681-019-2504-4
Abstract: Citrullus mucosospermus (egusi watermelon) and Citrullus lanatus (dessert watermelon) are closely related subspecies. Variation in their seed coats underlies a key to understand the major differences in seeds between these two subspecies. Although the genetic… read more here.
Keywords: seed; mapping; watermelon; egusi seed ... See more keywords
GG13: a candidate gene related to seed development and viability from apomictic Paspalum notatum
Sign Up to like & getrecommendations! Published in 2021 at "Euphytica"
DOI: 10.1007/s10681-021-02881-1
Abstract: One way to transfer apomixis (asexual reproduction through seeds) to major crops could be through genetic transformation, but for this a set of transgenes that triggers each of the involved processes should be generated. Although… read more here.
Keywords: seed; paspalum notatum; candidate gene; gene ... See more keywords
A candidate gene of Alzheimer diseases was mutated in senescence-accelerated mouse prone (SAMP) 8 mice.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.07.095
Abstract: The senescence-accelerated mouse prone (SAMP) 8 strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. We have found strong association of chromosome 12 locus with learning memory deficit (LMD) phenotype in… read more here.
Keywords: senescence accelerated; accelerated mouse; slc24a4; candidate gene ... See more keywords
A predicted NEDD8 conjugating enzyme gene identified as a Capsicum candidate Rf gene using bulk segregant RNA sequencing
Sign Up to like & getrecommendations! Published in 2020 at "Horticulture Research"
DOI: 10.1038/s41438-020-00425-7
Abstract: Cytoplasmic male sterility (CMS) is an important tool for producing F 1 hybrids, which can exhibit heterosis. The companion system, restorer-of-fertility ( Rf ), is poorly understood at the molecular level and would be valuable… read more here.
Keywords: nedd8 conjugating; conjugating enzyme; rna sequencing; segregant rna ... See more keywords
Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07737-0
Abstract: More than 1000 candidate-gene association studies on genetic susceptibility to lung cancer have been published over the last two decades but with few consensuses for the likely culprits. We conducted a comprehensive review, meta-analysis and… read more here.
Keywords: evidence; candidate gene; lung cancer; cancer ... See more keywords
Genome-Wide Linkage-Disequilibrium Mapping to the Candidate Gene Level in Melon (Cucumis melo)
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09987-4
Abstract: Cucumis melo is highly diverse for fruit traits providing wide breeding and genetic research opportunities, including genome-wide association (GWA) analysis. We used a collection of 177 accessions representing the two C. melo subspecies and 11… read more here.
Keywords: genome wide; gene level; melon; cucumis melo ... See more keywords
A candidate gene association analysis identifies SNPs potentially involved in drought tolerance in European beech (Fagus sylvatica L.)
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81594-w
Abstract: Studies of genetic variation underlying traits related to drought tolerance in forest trees are of great importance for understanding their adaptive potential under a climate change scenario. In this study, using a candidate gene approach,… read more here.
Keywords: candidate gene; european beech; drought tolerance; beech fagus ... See more keywords
The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies
Sign Up to like & getrecommendations! Published in 2017 at "Translational Psychiatry"
DOI: 10.1038/tp.2016.261
Abstract: Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene studies have identified genetic variants associated with cardiovascular diseases, metabolic diseases and mood disorders. Although previous efforts were successful for individual disease conditions (single disease), limited… read more here.
Keywords: genome wide; cardiometabolic diseases; mood disorders; mood ... See more keywords
A disulfide bond A-like oxidoreductase is a strong candidate gene for self-incompatibility in apricot (Prunus armeniaca) pollen
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erx336
Abstract: A disulfide bond A-like oxidoreductase encoded by a pollen modifier candidate gene is required for gametophytic self-incompatibility in apricot (Prunus armeniaca) as supported by loss-of-function mutations. read more here.
Keywords: disulfide bond; bond like; like oxidoreductase; incompatibility apricot ... See more keywords