Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
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DOI: 10.1021/acs.jmedchem.3c02153
Abstract: Herein, we report the hit-to-lead identification of a drug-like pleuromutilin conjugate 16, based on a triaromatic hit reported in 2020. The lead arose as the clear candidate from a hit-optimization campaign in which Gram-positive antibacterial… read more here.
Keywords: hit lead; candidate hit; pleuromutilin; antibiotic candidate ... See more keywords