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   Articles with "canine cell" as a keyword



Optimizing canine T cell activation, expansion, and transduction

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recommendations! Published in 2025 at "PLOS One"

DOI: 10.1101/2025.04.26.650803

Abstract: Dogs are becoming an important model for human cancers, and successfully troubleshooting issues with genetically modified T cell immunotherapy for round cell and solid neoplasms in dogs provides a unique opportunity to improve efficacy, safety,… read more here.

Keywords: transduction; cell activation; cell; stimulation ... See more keywords

Programmed death ligand 1 is expressed in canine B cell lymphoma and downregulated by MEK inhibitors

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recommendations! Published in 2017 at "Veterinary and Comparative Oncology"

DOI: 10.1111/vco.12297

Abstract: Programmed death ligand 1 (PD-L1) expression in antigen-presenting cells and tumors can inhibit T cell-mediated immunity. In this study, PD-L1 mRNA and protein expression was evaluated in canine B cell lymphoma (CLL17-71), large T-cell leukemia… read more here.

Keywords: programmed death; death ligand; canine cell; cell ... See more keywords

Canine T cell lymphoma treated with lomustine, vincristine, procarbazine, and prednisolone chemotherapy in 35 dogs.

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recommendations! Published in 2018 at "Veterinary and comparative oncology"

DOI: 10.1111/vco.12430

Abstract: Canine T cell lymphoma has previously been found to be a poor prognostic indicator compared with its B cell counterpart. The cyclophosphamide, doxorubicin, vincristine, and prednisolone protocol is widely accepted as a first line treatment… read more here.

Keywords: protocol; prednisolone; canine cell; vincristine ... See more keywords

An Antibody Specific for the Dog Leukocyte Antigen DR (DLA-DR) and Its Novel Methotrexate Conjugate Inhibit the Growth of Canine B Cell Lymphoma

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recommendations! Published in 2019 at "Cancers"

DOI: 10.3390/cancers11101438

Abstract: Canine B-cell lymphoma (CBL) is an incurable, spontaneous lymphoid malignancy constituting an accurate animal model for testing novel therapeutic strategies in human medicine. Resources of available species-specific therapeutic monoclonal antibodies (mAbs) targeting CBL are scarce.… read more here.

Keywords: canine cell; canine; dla; cell lymphoma ... See more keywords

Canine B Cell Lymphoma- and Leukemia-Derived Extracellular Vesicles Moderate Differentiation and Cytokine Production of T and B Cells In Vitro

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23179831

Abstract: Extracellular vesicles (EVs) are formed in physiological and pathological conditions by almost all mammalian cells. They are known as submicron “molecules” that transport and horizontally transfer their cargo from maternal cells to donor cells. Moreover,… read more here.

Keywords: extracellular vesicles; cell lymphoma; leukemia derived; canine cell ... See more keywords