Characterization of neurological disease progression in a canine model of CLN5 neuronal ceroid lipofuscinosis.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental neurobiology"
DOI: 10.1002/dneu.22878
Abstract: Golden Retriever dogs with a frameshift variant in CLN5 (c.934_935delAG) suffer from a progressive neurodegenerative disorder analogous to the CLN5 form of neuronal ceroid lipofuscinosis (NCL). Five littermate puppies homozygous for the deletion allele were… read more here.
Keywords: neuronal ceroid; ceroid lipofuscinosis; disease progression; progression ... See more keywords
Clinical and pathological characterization of ophthalmic disease in a canine model of mucopolysaccharidosis type I
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12587
Abstract: Mucopolysaccharidosis type I (MPS I) is a rare lysosomal storage disease caused by α‐L‐iduronidase enzyme deficiency, resulting in glycosaminoglycan (GAG) accumulation in various cell types, including ocular tissues. Ocular manifestations in humans are common with… read more here.
Keywords: disease; clinical pathological; mucopolysaccharidosis type; canine model ... See more keywords
QSM in canine model of acute cerebral ischemia: A pilot study
Sign Up to like & getrecommendations! Published in 2020 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.28498
Abstract: In the present study, we investigated the potential of QSM to assess the physiological state of cortical tissue in the middle cerebral artery occlusion canine model of a cerebral ischemia. read more here.
Keywords: cerebral ischemia; canine model; study;
Canine Model of Pacing-Induced Heart Failure.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8597-5_24
Abstract: Tachypacing-induced heart failure is a well-established large animal model that recapitulates numerous pathophysiological, structural and molecular features of dilated cardiomyopathy and, more in general, of end-stage congestive heart failure. The left or the right ventricle… read more here.
Keywords: heart; canine model; induced heart; heart failure ... See more keywords
Aldosterone stimulation mediates cardiac metabolism remodeling via Sirt1/AMPK signaling in canine model
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01641-2
Abstract: Aldosterone (Aldo), a pivotal hormone that is ubiquitously expressed in systemic tissues of mammals, is a crucial factor in the pathogenesis of cardiac disease. Accumulating evidence suggests that disturbances in cell energy metabolism are involved… read more here.
Keywords: aldosterone stimulation; aldosterone; sirt1 ampk; metabolism ... See more keywords
Ionic mechanisms underlying atrial electrical remodeling after a fontan-style operation in a canine model
Sign Up to like & getrecommendations! Published in 2020 at "Heart and Vessels"
DOI: 10.1007/s00380-019-01544-5
Abstract: Atrial arrhythmia is an important cause of late death in patients after the Fontan-Style operation. However, the detailed electrophysiological characteristics of the post-Fontan atrium and its underlying mechanisms are largely unknown. In this study, we… read more here.
Keywords: style operation; fontan style; operation; fontan operation ... See more keywords
Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2021.05.012
Abstract: BACKGROUND Both gap junctional remodeling and interstitial fibrosis have been linked to impaired electrical conduction velocity (CV) and fatal ventricular arrhythmias in nonischemic heart failure (HF). However, the arrhythmogenic role of the ventricular gap junctional… read more here.
Keywords: arrhythmogenic canine; canine; cx43; canine model ... See more keywords
Progressive Obstruction of Inferior Vena Cava by Ameroid Constrictor: The Canine Model of Revealing Hemodynamic and Compensatory Patterns of Tumor Thrombus Formation at The Renal Hilus Level.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of endourology"
DOI: 10.1089/end.2021.0760
Abstract: BACKGROUND To develop an efficient and stable canine model of IVC progressive obstruction at the renal hilus level. METHODS The model was established in two beagles by encircling an ameroid constrictor on the IVC at… read more here.
Keywords: renal hilus; canine model; hilus level; progressive obstruction ... See more keywords
Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.07.13.499876
Abstract: The health benefits of regular physical exercise are well known. Even so, there is increasing evidence that the exercise regimes of elite athletes can evoke cardiac arrhythmias including ventricular fibrillation and even sudden cardiac death… read more here.
Keywords: associated enhanced; electrophysiological remodeling; susceptibility; model ... See more keywords
Construction of a canine model with acute type B aortic dissection using a self-made pressure-driven flow device
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Animals"
DOI: 10.1538/expanim.22-0073
Abstract: A reproducible canine aortic dissection (AD) model would be useful for evaluating the performance of novel endovascular treatment devices. Therefore, we attempted to create a reproducible canine model of Stanford type B AD (TBAB) by… read more here.
Keywords: false lumen; aortic dissection; model; canine model ... See more keywords
A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.666348
Abstract: Ivermectin (IVM) and moxidectin (MOX) are used extensively as parasiticides in veterinary medicine. Based on in vitro data, IVM has recently been proposed for the prevention and treatment of COVID-19 infection, a condition for which… read more here.
Keywords: obesity; canine model; body weight; mox ... See more keywords