Articles with "canine models" as a keyword



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Gene therapies in canine models for Duchenne muscular dystrophy

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Published in 2019 at "Human Genetics"

DOI: 10.1007/s00439-019-01976-z

Abstract: Therapies for Duchenne muscular dystrophy (DMD) must first be tested in animal models to determine proof-of-concept, efficacy, and importantly, safety. The murine and canine models for DMD are genetically homologous and most commonly used in… read more here.

Keywords: canine models; therapies canine; muscular dystrophy; gene ... See more keywords
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Canine models of human amelogenesis imperfecta: identification of novel recessive ENAM and ACP4 variants

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Published in 2019 at "Human Genetics"

DOI: 10.1007/s00439-019-01997-8

Abstract: Amelogenesis imperfecta (AI) refers to a genetically and clinically heterogeneous group of inherited disorders affecting the structure, composition, and quantity of tooth enamel. Both non-syndromic and syndromic forms of AI have been described and several… read more here.

Keywords: canine models; amelogenesis imperfecta; enam; novel recessive ... See more keywords
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Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration

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Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0177224

Abstract: We have analyzed the complex pattern of the inflammatory response in early-onset canine models of human retinitis pigmentosa, rcd1, xlpra2 and erd, as well as late-onset xlpra1, in comparative manner. The time course of immune… read more here.

Keywords: canine models; early onset; response; inflammatory genes ... See more keywords
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Investigation of Beraprost Sodium on Cardiac Function and Hemodynamics in Canine Models of Chronic Pulmonary Hypertension

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Published in 2022 at "Frontiers in Veterinary Science"

DOI: 10.3389/fvets.2022.876178

Abstract: Pulmonary hypertension (PH) is a life-threatening disease in dogs characterized by increased pulmonary arterial pressure (PAP) and/or pulmonary vascular resistance. No study has evaluated the utility of Beraprost sodium (BPS) in dogs with PH. This… read more here.

Keywords: beraprost sodium; pulmonary hypertension; hemodynamics; bps ... See more keywords