Cannabidiol impairs neural tube closure in mouse whole embryo culture
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2013
Abstract: Cannabidiol (CBD) is a nonpsychoactive constituent of cannabis widely available as a dietary supplement. Previous reports that it impairs the retinoid, sonic hedgehog, and folate metabolism pathways raise concern that it may impair closure of… read more here.
Keywords: impairs neural; cannabidiol; closure; cannabidiol impairs ... See more keywords
Cannabidiol‐Loaded Poly Lactic‐Co‐Glycolic Acid Nanoparticles with Improved Bioavailability as a Potential for Osteoarthritis Therapeutic
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200698
Abstract: Cannabidiol (CBD) is a non‐intoxicating cannabinoid from cannabis sativa that has demonstrated efficacious against inflammation, which can be considered as a potential drug for arthritis treatment. However, the poor solubility and low bioavailability limit its… read more here.
Keywords: cbd plga; cannabidiol; bioavailability; plga nps ... See more keywords
Pharmacokinetic Drug-Drug Interaction With Coadministration of Cannabidiol and Everolimus in a Phase 1 Healthy Volunteer Trial.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1262
Abstract: When highly purified cannabidiol (CBD; Epidiolex) and the mammalian target of rapamycin inhibitor everolimus are used concomitantly in the treatment of tuberous sclerosis complex, there is evidence of a pharmacokinetic (PK) interaction, leading to increased… read more here.
Keywords: interaction; everolimus; cannabidiol; concentration ... See more keywords
Engineered Nucleotide Chemicapacitive Microsensor Array Augmented with Physics-Guided Machine Learning for High-Throughput Screening of Cannabidiol.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202107659
Abstract: The recent legalization of cannabidiol (CBD) to treat neurological conditions such as epilepsy has sparked rising interest across global pharmaceuticals and synthetic biology industries to engineer microbes for sustainable synthetic production of medicinal CBD. Since… read more here.
Keywords: physics; cannabidiol; high throughput; physics guided ... See more keywords
[Cannabidiol in cancer treatment].
Sign Up to like & getrecommendations! Published in 2020 at "Schmerz"
DOI: 10.1007/s00482-019-00438-9
Abstract: BACKGROUND Cannabis was used for cancer patients as early as about 2500 years ago. Experimental studies demonstrated tumor-inhibiting activities of various cannabinoids more than 40 years ago. In view of the status of tetrahydrocannabinol (THC) as a regulated… read more here.
Keywords: cbd; cannabidiol; cancer treatment; cancer ... See more keywords
Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn’s Disease, a Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-017-4540-z
Abstract: BackgroundCannabidiol (CBD) is an anti-inflammatory cannabinoid shown to be beneficial in a mouse model of IBD. Lacking any central effect, cannabidiol is an attractive option for treating inflammatory diseases.AimTo assess the effects of cannabidiol on… read more here.
Keywords: treatment; cannabidiol; cbd; crohn disease ... See more keywords
Emerging potential of cannabidiol in reversing proteinopathies
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101209
Abstract: The aberrant accumulation of disease-specific protein aggregates accompanying cognitive decline is a pathological hallmark of age-associated neurological disorders, also termed as proteinopathies, including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and multiple sclerosis.… read more here.
Keywords: emerging potential; proteostasis network; cannabidiol; disease ... See more keywords
Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers.
Sign Up to like & getrecommendations! Published in 2017 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2016.11.030
Abstract: BACKGROUND Cannabidiol (CBD) is a naturally occurring constituent of the marijuana plant. In the past few years, there has been great interest in the therapeutic effects of isolated CBD and it is currently being explored… read more here.
Keywords: marijuana; abuse liability; cannabidiol; oral cannabidiol ... See more keywords
Cannabidiol selectively inhibits the contraction of rat small resistance arteries: possible role for CGRP and voltage-gated calcium channels.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173767
Abstract: The pharmacology of cannabidiol, the non-psychoactive major component of Cannabis sativa, is of growing interest as it becomes more widely prescribed. This study aimed to examine the effects of cannabidiol on a wide range of… read more here.
Keywords: resistance arteries; calcium channels; small resistance; pharmacology ... See more keywords
The unexpected identification of the cannabimimetic, 5F-ADB, and dextromethorphan in commercially available cannabidiol e-liquids.
Sign Up to like & getrecommendations! Published in 2019 at "Forensic science international"
DOI: 10.1016/j.forsciint.2018.10.019
Abstract: Electronic cigarettes (e-cigarettes) were developed as an alternative method for nicotine delivery and had a significant surge in popularity. E-liquids are formulations used in e-cigarettes, and consist of a ratio of propylene glycol (PG) and… read more here.
Keywords: adb dextromethorphan; identification cannabimimetic; unexpected identification; cannabidiol ... See more keywords
Two-weeks treatment with cannabidiol improves biophysical and behavioral deficits associated with experimental type-1 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135020
Abstract: The prevalence rates of depression and anxiety are at least two times higher in diabetic patients, increasing morbidity and mortality. Cannabidiol (CBD) has been identified as a therapeutic agent viable to treat diverse psychiatric disorders.… read more here.
Keywords: cbd; associated experimental; treatment; two weeks ... See more keywords