The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogs.
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DOI: 10.1002/dta.2583
Abstract: 5F-PY-PICA and 5F-PY-PINACA are pyrrolidinyl 1-(5-fluoropentyl)ind (az)ole-3-carboxamides identified in 2015 as putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS). 5F-PY-PICA, 5F-PY-PINACA, and analogs featuring variation of the 1-alkyl substituent or contraction, expansion, or… read more here.
Keywords: pica pinaca; cannabinoid receptor; pharmacology; chemistry ... See more keywords
Large-scale evaluation of ion mobility spectrometry for the rapid detection of synthetic cannabinoid receptor agonists in infused papers in prisons.
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DOI: 10.1002/dta.2945
Abstract: Synthetic cannabinoid receptor agonists (SCRAs), colloquially known as "spice," are commonly used in prisons and enter establishments via the mail in the form of infused papers. Many prisons use benchtop Ion Mobility Spectroscopy (IMS) instruments… read more here.
Keywords: detection; infused papers; mobility; synthetic cannabinoid ... See more keywords
A transnational perspective on the evolution of the synthetic cannabinoid receptor agonists market: Comparing prison and general populations.
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DOI: 10.1002/dta.3002
Abstract: The synthetic cannabinoid receptor agonist (SCRA) market is transnational and the availability of individual SCRAs changes regularly in response to national and international legislative controls. This generates a cyclic pattern and near constant evolution of… read more here.
Keywords: scra; cannabinoid receptor; synthetic cannabinoid; market ... See more keywords
Synthetic cannabinoid receptor agonists and their human metabolites in sewage water: Stability assessment and identification of transformation products.
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DOI: 10.1002/dta.3129
Abstract: Since their first appearance in 2008, synthetic cannabinoid receptor agonists (SCRAs) remain the most popular new psychoactive substances (NPS) in the EU. Following consumption, these drugs and their metabolites are urinary excreted and enter the… read more here.
Keywords: sewage water; synthetic cannabinoid; receptor agonists; cannabinoid receptor ... See more keywords
Cannabinoid receptor activation potential of the next generation, generic ban evading OXIZID synthetic cannabinoid receptor agonists.
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DOI: 10.1002/dta.3283
Abstract: In recent years, several nations have implemented various measures to control the surge of new synthetic cannabinoid receptor agonists (SCRAs) entering the recreational drug market. In July 2021, China put into effect a new generic… read more here.
Keywords: poxizid; bzo; synthetic cannabinoid; cannabinoid receptor ... See more keywords
A new cannabinoid receptor 1 selective agonist evading the 2021 'China ban': ADB-FUBIATA.
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DOI: 10.1002/dta.3285
Abstract: Following the class-wide ban of synthetic cannabinoid receptor agonists (SCRAs) in China, SCRAs carrying new core and linker structures, aimed at circumventing the recent Chinese generic legislation, have appeared on the recreational drug market. A… read more here.
Keywords: adb; cannabinoid receptor; adb fubiata; ban ... See more keywords
Interplay of Liver–Heart Inflammatory Axis and Cannabinoid 2 Receptor Signaling in an Experimental Model of Hepatic Cardiomyopathy
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DOI: 10.1002/hep.30916
Abstract: Hepatic cardiomyopathy, a special type of heart failure, develops in up to 50% of patients with cirrhosis and is a major determinant of survival. However, there is no reliable model of hepatic cardiomyopathy in mice.… read more here.
Keywords: cannabinoid receptor; hepatic cardiomyopathy; model hepatic; heart ... See more keywords
Diet‐Induced Obesity in Cannabinoid‐2 Receptor Knockout Mice and Cannabinoid Receptor 1/2 Double‐Knockout Mice
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DOI: 10.1002/oby.22403
Abstract: Evidence suggests that cannabinoid‐1 receptor (CB1R) activation is associated with increased food intake and body weight gain. Human epidemiological studies, however, show decreased prevalence of obesity in cannabis users. Given the overlapping and complementary functions… read more here.
Keywords: knockout mice; cannabinoid receptor; mice;
Effects of the cannabinoid receptor agonist CP-55,940 on incentive salience attribution
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DOI: 10.1007/s00213-020-05571-3
Abstract: Pavlovian conditioned approach paradigms are used to characterize the nature of motivational behaviors in response to stimuli as either directed toward the cue (i.e., sign-tracking) or the site of reward delivery (i.e., goal-tracking). Recent evidence… read more here.
Keywords: sign tracking; goal; cannabinoid receptor; incentive salience ... See more keywords
Modulation of Excitatory Synaptic Transmission During Cannabinoid Receptor Activation.
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DOI: 10.1007/s10571-021-01074-7
Abstract: The present research has reported that cannabinoid receptor 1 (CB1) agonist, delta-(9)-tetrahydrocannabinol (THC) modulates synaptogenesis during overexcitation. Microtubule and synaptic distribution, poly(ADP)-ribose (PAR) accumulation were estimated during overexcitation and in the presence of THC. Low concentration… read more here.
Keywords: concentration thc; cannabinoid receptor; glutamate; thc ... See more keywords
Selective Activation of Cannabinoid Receptor 2 Attenuates Myocardial Infarction via Suppressing NLRP3 Inflammasome
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DOI: 10.1007/s10753-018-0945-x
Abstract: The administration of cannabinoid receptor 2 (CB2R) agonist has been reported to produce a cardioprotective effect against the pathogenesis and progression of myocardial infarction (MI). Here in this study, we investigated the specific mechanism related… read more here.
Keywords: myocardial infarction; jwh 133; cannabinoid receptor; activation ... See more keywords