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   Articles with "canonical amino" as a keyword



Expanding the Diversity of Nitroxide‐Based Paramagnetic Probes Conjugated to Non‐Canonical Amino Acids for Sdsl‐Epr Applications

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recommendations! Published in 2025 at "Chembiochem"

DOI: 10.1002/cbic.202500064

Abstract: Understanding protein structure requires studying its dynamics, which is critical to elucidating its functional role. Biophysical techniques have revolutionized this field over time, providing remarkable insights into structure‐function relationships. Among these, Site‐Directed Spin Labelling (SDSL)… read more here.

Keywords: amino acids; protein; canonical amino; non canonical ... See more keywords

Site‐specifically Incorporated Non‐Canonical Amino Acids into Pseudomonas alcaligenes Lipase to Hydrolyze L‐menthol Propionate among the Eight Isomers

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recommendations! Published in 2021 at "ChemCatChem"

DOI: 10.1002/cctc.202100358

Abstract: It remains a challenge to improve the diastereopreference of enzymes when there are multiple chiral centers in the substrate, mainly because the limited understanding of mechanism determining diastereoselectivity. Compared with natural amino acids, non‐canonical amino… read more here.

Keywords: non canonical; canonical amino; amino acids; menthol propionate ... See more keywords
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From Folding to Assembly: Functional Supramolecular Architectures of Peptides Comprised of Non-Canonical Amino Acids.

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recommendations! Published in 2021 at "Macromolecular bioscience"

DOI: 10.1002/mabi.202100090

Abstract: The engineering of biological molecules is the fundamental concept behind the design of complex materials with desirable functions. Over the last few decades, peptides and proteins have emerged as useful building blocks for well-defined nanostructures… read more here.

Keywords: amino acids; folding assembly; non canonical; canonical amino ... See more keywords

Generating Efficient Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetases for Structurally Diverse Non-Canonical Amino Acids.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.2c00639

Abstract: Genetic code expansion (GCE) technologies commonly use the pyrrolysyl-tRNA synthetase (PylRS)/tRNAPyl pairs from Methanosarcina mazei (Mm) and Methanosarcina barkeri (Mb) for site-specific incorporation of non-canonical amino acids (ncAAs) into proteins. Recently a homologous PylRS/tRNAPyl pair… read more here.

Keywords: pylrs; non canonical; canonical amino; pyrrolysyl trna ... See more keywords

Optimized Bioorthogonal Non-canonical Amino Acid Tagging to Identify Serotype-Specific Biomarkers in Verotoxigenic Escherichia coli.

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recommendations! Published in 2023 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.2c00548

Abstract: According to Canada's Food Report Card 2016, there are 4 million foodborne illnesses acquired each year in the nation alone. The leading causes of foodborne illness are pathogenic bacteria such as shigatoxigenic/verotoxigenic Escherichia coli (STEC/VTEC)… read more here.

Keywords: escherichia coli; non canonical; canonical amino; bioorthogonal non ... See more keywords

Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery.

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recommendations! Published in 2023 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.3c00037

Abstract: Life is constructed primarily using a toolbox of 20 canonical amino acids-relying upon these building blocks for the assembly of proteins and peptides that regulate nearly every cellular task, including cell structure, function, and maintenance.… read more here.

Keywords: amino acids; drug; canonical amino; drug discovery ... See more keywords
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A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design

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recommendations! Published in 2021 at "Nature Chemistry"

DOI: 10.1038/s41557-021-00764-5

Abstract: Orthogonal (O) ribosome-mediated translation of O-mRNAs enables the incorporation of up to three distinct non-canonical amino acids (ncAAs) into proteins in Escherichia coli (E. coli). However, the general and efficient incorporation of multiple distinct ncAAs… read more here.

Keywords: four distinct; amino acids; non canonical; canonical amino ... See more keywords
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Chemically-defined lactose-based autoinduction medium for site-specific incorporation of non-canonical amino acids into proteins

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recommendations! Published in 2018 at "Rsc Advances"

DOI: 10.1039/c8ra04359k

Abstract: Optimized chemically-defined lactose-based autoinduction media for superior expression levels of proteins with non-canonical amino acids. read more here.

Keywords: based autoinduction; non canonical; defined lactose; lactose based ... See more keywords

Employing non-canonical amino acids towards the immobilization of a hyperthermophilic enzyme to increase protein stability

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recommendations! Published in 2023 at "RSC Advances"

DOI: 10.1039/d3ra00392b

Abstract: A carboxylesterase derived from Sulfolobus solfataricus P1 was immobilized onto an epoxy-activated Sepharose resin via non-canonical amino acids. The immobilized enzyme exhibited heightened performance in organic solvents, recyclability, and stability at room temperature for over… read more here.

Keywords: immobilization; amino acids; non canonical; canonical amino ... See more keywords

Mechanisms and minimization of false discovery of metabolic bio-orthogonal non-canonical amino acid proteomics.

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recommendations! Published in 2022 at "Rejuvenation research"

DOI: 10.1089/rej.2022.0019

Abstract: Metabolic proteomics has been widely used to characterize dynamic protein networks in many areas of biomedicine, including in the arena of tissue aging and rejuvenation. Bio-orthogonal non-canonical amino acid tagging (BONCAT) is based on mutant… read more here.

Keywords: bio orthogonal; orthogonal non; false discovery; non canonical ... See more keywords

PepLand: a large-scale pre-trained peptide representation model for a comprehensive landscape of both canonical and non-canonical amino acids

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recommendations! Published in 2025 at "Briefings in Bioinformatics"

DOI: 10.1093/bib/bbaf367

Abstract: Abstract The recent interest in peptides incorporating non-canonical amino acids has surged within the scientific community, driven by their enhanced stability and resistance to proteolytic degradation. These so-called non-canonical peptides offer significant potential for modifying… read more here.

Keywords: canonical non; pre; amino acids; canonical amino ... See more keywords