Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides.
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DOI: 10.1007/164_2016_5001
Abstract: Contemporary investigations regarding the (patho)physiological roles of the non-canonical cyclic nucleoside monophosphates (cNMP) cytidine 3',5'-cyclic monophosphate (cCMP) and uridine 3',5'-cyclic monophosphate (cUMP) have been hampered by the lack of highly specific and sensitive analytic methods… read more here.
Keywords: mass spectrometric; canonical cyclic; non canonical; cyclic nucleotides ... See more keywords
Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport.
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DOI: 10.1007/164_2016_5004
Abstract: This chapter addresses cNMP hydrolysis by phosphodiesterases (PDEs) and export by multidrug resistance associated proteins (MRPs). Both mechanisms are well-established for the canonical cNMPs, cAMP, and cGMP. Increasing evidence shows that non-canonical cNMPs (specifically cCMP,… read more here.
Keywords: canonical cnmps; canonical cyclic; non canonical; hydrolysis ... See more keywords
Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode
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DOI: 10.1007/s00210-018-1582-5
Abstract: The non-canonical cyclic nucleotide cUMP and the phosphodiesterase PDE9A both occur in neuronal cells. Using HPLC-coupled tandem mass spectrometry, we characterized the kinetics of PDE9A-mediated cUMP hydrolysis. PDE9A is a low-affinity and high-velocity enzyme for… read more here.
Keywords: pde9a; cyclic nucleotide; canonical cyclic; non canonical ... See more keywords