Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.7b00484
Abstract: IKKβ plays a central role in the canonical NF-kB pathway, which has been extensively characterized. The role of IKKα in the noncanonical NF-kB pathway, and indeed in the canonical pathway as a complex with IKKβ,… read more here.
Keywords: canonical pathway; inhibitory kappa; kappa kinase; pathway ... See more keywords
Clinical benefit of ixazomib plus lenalidomide‐dexamethasone in myeloma patients with non‐canonical NF‐κB pathway activation
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Haematology"
DOI: 10.1111/ejh.13435
Abstract: Abstract Objectives Evaluating potential relationships between progression‐free survival (PFS) and tumor gene expression patterns and mutational status was an exploratory objective of the phase 3 TOURMALINE‐MM1 study (NCT01564537) of ixazomib‐lenalidomide‐dexamethasone (IRd) vs placebo‐Rd in 722… read more here.
Keywords: non canonical; pathway activation; expression; canonical pathway ... See more keywords
Targeted Pyroptosis Is a Potential Therapeutic Strategy for Cancer
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DOI: 10.1155/2022/2515525
Abstract: As a type of regulated cell death (RCD) mode, pyroptosis plays an important role in several kinds of cancers. Pyroptosis is induced by different stimuli, whose pathways are divided into the canonical pathway and the… read more here.
Keywords: cancer; pyroptosis; noncanonical pathway; canonical pathway ... See more keywords
Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway
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DOI: 10.1159/000480313
Abstract: Background/Aims: Alcohol (ethanol, EtOH) as significant contributor to traumatic injury is linked to suppressed inflammatory response, thereby influencing clinical outcomes. Alcohol-induced immune-suppression during acute inflammation (trauma) was linked to nuclear factor-kappaB (NF-ĸB). Here, we analyzed… read more here.
Keywords: canonical pathway; epithelial cells; lung epithelial; inflammatory response ... See more keywords
The relationship between the non-canonical NF-κB pathway, tumour microenvironment, systemic inflammation and survival in patients undergoing surgery for colorectal caner.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.631
Abstract: 631Background: In patients with colorectal cancer (CRC) the local and systemic inflammatory responses (LIR and SIR) are important determinants of disease progression. The present study examines the association of transcription factor RelB, a key member… read more here.
Keywords: canonical pathway; patients undergoing; relb; non canonical ... See more keywords